Tag: p53 Activator|Inhibitor

For research use only. We do not sell to patients. Tenovin-6 CAS No. : 1011557-82-6 Biological Activity：Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also […]

For research use only. We do not sell to patients. CBL0137 hydrochloride CAS No. : 1197397-89-9 Biological Activity：CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 µM, respectively. Research Area：Cancer Targets：NF-κB|MDM-2/p53 Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound […]

For research use only. We do not sell to patients. Inauhzin CAS No. : 309271-94-1 Biological Activity：Inauhzin is a dual SirT1/IMPDH2 inhibitor, and acts as an activator p53, used in the research of cancer. Research Area：Cancer Targets：Sirtuin|MDM-2/p53 Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. MRT00033659 CAS No. : 1401731-54-1 Biological Activity：MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation. Research Area：Cancer Targets：Casein Kinase|MDM-2/p53|Checkpoint Kinase (Chk)|Early 2 Factor (E2F) Related Screening […]

For research use only. We do not sell to patients. Tenovin-1 CAS No. : 380315-80-0 Biological Activity：Tenovin-1, a p53 activator, protects p53 from MDM2-mediated degradation. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor[2]. Research Area：Cancer Targets：Autophagy|Dihydroorotate Dehydrogenase|Sirtuin|MDM-2/p53 Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis […]