Tag: p53 Activator|Activator

For research use only. We do not sell to patients. PK11007 CAS No. : 874146-69-7 Biological Activity：PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels[2]. […]

For research use only. We do not sell to patients. Amifostine CAS No. : 20537-88-6 Biological Activity：Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived […]

For research use only. We do not sell to patients. PRIMA-1 CAS No. : 5608-24-2 Biological Activity：PRIMA-1 (NSC-281668) is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A. Research Area：Cancer Targets：Ferroptosis|Autophagy|MDM-2/p53|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound […]

For research use only. We do not sell to patients. DPBQ CAS No. : 7029-89-2 Biological Activity：DPBQ activates p53 and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind DNA. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Research Area：Cancer Targets：MDM-2/p53|Apoptosis Related Small Molecules:Physalin […]

For research use only. We do not sell to patients. Verminoside CAS No. : 50932-19-9 Biological Activity：Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of PARP-1 and p53 proteins[2][3]. Research […]

For research use only. We do not sell to patients. COTI-2 CAS No. : 1039455-84-9 Biological Activity：COTI-2, an anti-cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI-2 acts both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. COTI-2 induces apoptosis in multiple human tumor cell lines. […]