Tag: Modulator

For research use only. We do not sell to patients. Cipralisant CAS No. : 213027-19-1 Biological Activity：Cipralisant (GT-2331) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for […]

For research use only. We do not sell to patients. TCN238 CAS No. : 125404-04-8 Biological Activity：TCN238 is an orally bioavailable mGlu4 receptor positive allosteric modulator (PAM) with an EC50 of 1 μM. Research Area：Neurological Disease Targets：mGluR Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Orally Active Compound Library;Neurotransmitter Receptor Compound Library; […]

For research use only. We do not sell to patients. N-Tetradecanoyl-L-homoserine lactone CAS No. : 202284-87-5 Biological Activity：N-Tetradecanoyl-L-homoserine lactone is a short-chained N-acyl homoserine lactone (AHL). Diatoms are frequently found in association with Proteobacteria, many members of which employ cell-to-cell communication via AHLs in aquatic habitats. Research Area：Infection Targets：Bacterial Related Small Molecules:Sandramycin;LLO (91-99);Gepotidacin;Oritavancin;Azlocillin sodium salt;Herbimycin […]

For research use only. We do not sell to patients. CPPHA CAS No. : 693288-97-0 Biological Activity：CPPHA is potent and selective positive allosteric modulator (PAM) of the mGluR5 and mGluR1 (metabotropic glutamate receptor). CPPHA can potentiate responses of mGluR5 and mGluR1 to activation of these receptors. CPPHA is developed for the research of central nervous […]

For research use only. We do not sell to patients. IL-17 modulator 4 CAS No. : 2446803-65-0 Biological Activity：IL-17 modulator 4 is a prodrug of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. Research Area：Inflammation/Immunology Targets：Interleukin Related Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:AX-024;Ginsenoside F3;Perakizumab;PNRI-299;CTX-471;Ac-YVAD-CHO;Deucravacitinib;Mulberroside A;NFAT […]

For research use only. We do not sell to patients. BPN-15606 CAS No. : 1914989-49-3 Biological Activity：BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Aβ42 and Aβ40 levels in the central […]

For research use only. We do not sell to patients. GABAA receptor modulator-2 CAS No. : 2413850-54-9 Biological Activity：GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABAAR negative allosteric modulator (NAM) with a Ki of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety. Research Area：Neurological Disease Targets：GABA Receptor Related Small Molecules:SKF89976A hydrochloride;mGAT-IN-1;Alpidem;FG8119;Valerenic […]

For research use only. We do not sell to patients. MRGPRX1 agonist 3 Biological Activity：MRGPRX1 agonist 3 (compound 1f) is a potent Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.22 μM. MRGPRX1 agonist 3 can be used for researching neuropathic pain. Research Area：Neurological Disease Targets：Others Related Small Molecules:Immune […]

For research use only. We do not sell to patients. GSK-2881078 CAS No. : 1539314-06-1 Biological Activity：GSK 2881078 is a selective androgen receptor modulator potentially for the treatment of cachexia. GSK 2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting […]

For research use only. We do not sell to patients. 4β-Hydroxycholesterol CAS No. : 17320-10-4 Biological Activity：4β-hydroxy Cholesterol is a major oxysterol cholesterol metabolite and a precursor in the synthesis of bile acids that is found in human circulation. Research Area：Metabolic Disease Targets：Endogenous Metabolite Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;2-Mercaptobenzothiazole;N-Acetyl-L-glutamic acid-d5;(3R,5S)-3-Hydroxy Cotinine-d3;Biliverdin hydrochloride;D-Glucose-13C,d1-3;2,3-Diaminopropionic acid […]