Tag: Modulator

For research use only. We do not sell to patients. NJH-2-056 Biological Activity：NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research. Research Area：Inflammation/Immunology Targets：CFTR|PROTACs Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Membrane Transporter/Ion Channel Compound Library; Related Small Molecules:PROTAC Sirt2 […]

For research use only. We do not sell to patients. Sirtuin modulator 2 CAS No. : 667910-69-2 Biological Activity：Sirtuin modulator 2 (Compound 132) is a sirtuin modulator with an ED50 equal or less than 50 μM. Research Area：Cancer|Metabolic Disease|Inflammation/Immunology|Neurological Disease|Cardiovascular Disease Targets：Sirtuin Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound […]

For research use only. We do not sell to patients. Palvanil CAS No. : 69693-13-6 Biological Activity：Palvanil is a Capsaicin (HY-10448) analogue, shows strong desensitizing capability against the TRPV1 receptor. Palvanil shows anti-nociceptive and anti-inflammation effects[2]. Research Area：Inflammation/Immunology|Neurological Disease Targets：TRP Channel Related Small Molecules:V116517;GSK2332255B;Pregnenolone monosulfate sodium;TRPC5-IN-4;OptoBI-1;SB-705498;TRPC3/6-IN-1;ABT-239;Pyr3;Asivatrep;Ononetin;TRPM8 antagonist 3;FEMA 4809;Hydroxy-α-sanshool;GsMTx4 TFA;TRPM4-IN-1;Pregnenolone monosulfate sodium-13C2,d2;Capsazepine;MSP-3;TRPM4-IN-2;Pregnenolone-d4-1;Umbellulone;Icilin;DS88790512;TRPV antagonist 1;ML-SA1 Trending […]

For research use only. We do not sell to patients. γ-Secretase modulator 11 hydrochloride CAS No. : 2434630-30-3 Biological Activity：γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride […]

For research use only. We do not sell to patients. Ipsapirone CAS No. : 95847-70-4 Biological Activity：Ipsapirone (TVX Q 7821) is an anxiolytic compound and a 5-HT1A receptor partial agonist. Ipsapirone (TVX Q 7821) also exhibits 5-HT1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT2 and […]

For research use only. We do not sell to patients. RL-0070933 CAS No. : 301326-41-0 Biological Activity：RL-0070933 is a potent smo cilial modulator with an EC50 value of 0.02 µM. RL-0070933 modulates the translocation and/or accumulation of smoothened to the primary cilia by hedgehog signaling pathway. Research Area：Cancer Targets：Smo|Hedgehog Related Small Molecules:Saikosaponin B1;MRT-10;LEQ506;RU-SKI 43;Dynarrestin;20(S)-Hydroxycholesterol;Sonidegib;PF-5274857 hydrochloride;SANT […]

For research use only. We do not sell to patients. BAP9THP CAS No. : 2312-73-4 Biological Activity：BAP9THP is a synthetic cytokinin derivative and a growth regulator. BAP9THP promotes chlorophyll retention (and senescence delay) in plant tissues exceptionally strongly, and growth of tobacco callus almost as strongly as 6-Benzylaminopurine (BAP). BAP9THP induces adventitious shoot formation ignificantly […]

For research use only. We do not sell to patients. Elexacaftor CAS No. : 2216712-66-0 Biological Activity：Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface. Research Area：Others Targets：CFTR|Autophagy Related […]

For research use only. We do not sell to patients. Raloxifene 6-Monomethyl Ether CAS No. : 178451-13-3 Biological Activity：Raloxifene 6-Monomethyl Ether (Compound 7) is a Raloxifene derivative that inhibits estrogen receptor α. Raloxifene 4-Monomethyl Ether inhibits MCF-7 cells with an IC50 of 250 nM and a pIC50 of 6.6. Targets：Estrogen Receptor/ERR Related Small Molecules:DS20362725;LSD1/ER-IN-1;Giredestrant;Avobenzone;Estriol-d3;Chrysin;ERRγ Inverse […]

For research use only. We do not sell to patients. IQ 1 CAS No. : 331001-62-8 Biological Activity：IQ 1 is a Wnt/β-catenin/CBP signalling sustainer. IQ 1 maintains long-term expansion of Wnt/β-catenin-driven mouse embryonic stem cells (ESCs) and prevents spontaneous differentiation by enhancing β-catenin/CBP-mediated transcription and preventing conversion to β-catenin/p300-mediated transcription. IQ-1 regulates Wnt signalling by […]