Tag: Modulator

For research use only. We do not sell to patients. ML372 CAS No. : 1331745-61-9 Biological Activity：ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo. Research Area：Neurological […]

For research use only. We do not sell to patients. Bradykinin (2-9) CAS No. : 16875-11-9 Biological Activity：Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P. Research Area：Cardiovascular Disease|Endocrinology Targets：Bradykinin Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Anti-Cardiovascular Disease Compound Library;Endocrinology Compound Library;Neurotransmitter Receptor […]

For research use only. We do not sell to patients. Estrogen receptor modulator 1 CAS No. : 63676-22-2 Biological Activity：Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors[2]. Research Area：Cancer Targets：Estrogen […]

For research use only. We do not sell to patients. Ulipristal CAS No. : 159811-51-5 Biological Activity：Ulipristal (CDB 3236) is a selective progesterone receptor modulator (SPRM). Ulipristal binds to the progesteron receptor, thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system. Research Area：Cancer|Endocrinology Targets：Progesterone Receptor Related Screening Libraries:Drug Repurposing Compound […]

For research use only. We do not sell to patients. VU0152100 CAS No. : 409351-28-6 Biological Activity：VU0152100 (VU152100) is a highly selective mAChR positive allosteric modulator (permeable to the blood-brain barrier). VU0152100 reverses Amphetamine-induced hypermotility in rats and increased levels of extracellular dopamine in nucleus accumbens and caudate-putamen. VU0152100 has good research potential in psychosis […]

For research use only. We do not sell to patients. Lubabegron CAS No. : 391920-32-4 Biological Activity：Lubabegron is a potent modulator of β-adrenergic receptor (β -AR). Lubabegron demonstrates antagonistic behavior at the β1 and β 2 receptor subtypes and agonistic behavior at the β 3 receptor subtype in cattle. Lubabegron reduces NH3 gas emissions from an animal […]

For research use only. We do not sell to patients. Tasquinimod CAS No. : 254964-60-8 Biological Activity：Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor[2][3]. Research Area：Cancer Targets：HDAC […]

For research use only. We do not sell to patients. Kv3 modulator 1 CAS No. : 1380696-64-9 Biological Activity：Kv3 modulator 1 is a Kv3 voltage-gated potassium channel modulator extracted from patent WO2018020263A1, Compound X. Kv3 modulator 1 has the potential for inflammatory pain treatment. Research Area：Inflammation/Immunology Targets：Potassium Channel Related Small Molecules:Kv3 modulator 2;Brompheniramine-d6 maleate;Pinacidil;AMP-PNP tetralithium;IK1 […]

For research use only. We do not sell to patients. SHR168442 CAS No. : 2382961-86-4 Biological Activity：SHR168442 is a modulator of retinoid-related orphan receptor gamma (RORγ) with an IC50 value of 0.035 μM. Research Area：Cancer|Inflammation/Immunology Targets：ROR Related Small Molecules:RORγt inhibitor 1;GNE-6468;SR3335;RORγt inverse agonist 30;GNE-0946;RORγt inverse agonist 13;Vimirogant hydrochloride;SR2211;Bevurogant;ROR agonist-1;RORγt Inverse agonist 8;CD12681;S18-000003;RORγt inhibitor 2;XY018;RORγt inverse […]

For research use only. We do not sell to patients. VPC 23019 CAS No. : 449173-19-7 Biological Activity：VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). […]