Tag: Inhibitor|Modulator

For research use only. We do not sell to patients. Palmatine hydroxide CAS No. : 131-04-4 Biological Activity：Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in […]

For research use only. We do not sell to patients. Atazanavir-d9 CAS No. : 1092540-51-6 Biological Activity：Atazanavir-d9 (BMS-232632-d9) is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of […]

For research use only. We do not sell to patients. Zn-DPA-maytansinoid conjugate 1 Biological Activity：Zn-DPA-maytansinoid conjugate 1 is a small molecule-based maytansinoid conjugate targeting immune checkpoint. Zn-DPA-maytansinoid conjugate 1 induces lasting regression of tumor growth and rejuvenates tumor microenvironment (TME) to an “inflamed hot tumor”. Research Area：Cancer Targets：CXCR|STAT|CCR|Checkpoint Kinase (Chk) Related Small Molecules:Nicotinamide N-oxide;Cirsilineol;Ochromycinone;C188-9;STAT3-IN-10;LMD-009;FC131;C188;CXCR4 antagonist […]

For research use only. We do not sell to patients. Palmatine chloride CAS No. : 10605-02-4 Biological Activity：Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in […]

For research use only. We do not sell to patients. Atazanavir-d5 CAS No. : 1132747-14-8 Biological Activity：Atazanavir-d5 is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein […]

For research use only. We do not sell to patients. Lacidipine CAS No. : 103890-78-4 Biological Activity：Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP […]

For research use only. We do not sell to patients. Vidofludimus CAS No. : 717824-30-1 Biological Activity：Vidofludimus is an orally active inhibitor for dihydroorotate dehydrogenase (DHODH) and also is a novel modulator for farnesoid X receptor (FXR). Vidofludimus, as an immunomodulatory agent, can be used for the research of autoimmune disorders such as inflammatory bowel […]

For research use only. We do not sell to patients. Glucocorticoid receptor modulator 1 Biological Activity：Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC50 value of 9 nM and 130 nM for NF-κB and AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression […]

For research use only. We do not sell to patients. TC14012 TFA Biological Activity：TC14012 TFA, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 TFA is a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 TFA has […]

For research use only. We do not sell to patients. Atazanavir-d6 CAS No. : 1092540-50-5 Biological Activity：Atazanavir-d6 is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. […]