Tag: Inhibitor|Inducer|Activator

For research use only. We do not sell to patients. Pregnenolone monosulfate sodium CAS No. : 1852-38-6 Biological Activity：Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol […]

For research use only. We do not sell to patients. Ivaltinostat formic Biological Activity：Ivaltinostat (CG-200745) formic is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic induces the accumulation of p53, promotes […]

For research use only. We do not sell to patients. Ionomycin CAS No. : 56092-81-0 Biological Activity：Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC)[2][3]. Research […]

For research use only. We do not sell to patients. SMTIN-T140 Biological Activity：SMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC50 of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in […]

For research use only. We do not sell to patients. Omaveloxolone CAS No. : 1474034-05-3 Biological Activity：Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling. Research Area：Cancer|Inflammation/Immunology Targets：Keap1-Nrf2|STING|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;Clinical […]

For research use only. We do not sell to patients. Isoniazid CAS No. : 54-85-3 Biological Activity：Isoniazid (INH) is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[2][3][4]. Research Area：Infection Targets：Autophagy|Mitophagy|Bacterial|Antibiotic Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. Pitavastatin CAS No. : 147511-69-1 Biological Activity：Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, […]