Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. YK-4-279 CAS No. : 1037184-44-3 Biological Activity：YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used […]

For research use only. We do not sell to patients. Paroxetine-d4 hydrochloride CAS No. : 2714485-95-5 Biological Activity：Paroxetine-d4 (hydrochloride) is deuterium labeled Paroxetine (hydrochloride). Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14 μM. Paroxetine hydrochloride can be used for the research of depressive […]

For research use only. We do not sell to patients. ASK1-IN-3 CAS No. : 2426705-19-1 Biological Activity：ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities. Research Area：Cancer|Inflammation/Immunology […]

For research use only. We do not sell to patients. 5-(N,N-Hexamethylene)-amiloride CAS No. : 1428-95-1 Biological Activity：5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion […]

For research use only. We do not sell to patients. Takinib CAS No. : 1111556-37-6 Biological Activity：Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. Takinib is an inhibitor of autophosphorylated […]

For research use only. We do not sell to patients. Spadin TFA Biological Activity：Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. […]

For research use only. We do not sell to patients. Domatinostat CAS No. : 910462-43-0 Biological Activity：Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Research […]

For research use only. We do not sell to patients. ALK-IN-22 CAS No. : 2468219-09-0 Biological Activity：ALK-IN-22 (compound I-24) is a potent ALK inhibitor with IC50 values of 2.3, 3.7 and 2.9 nM for ALK, ALKL1196M and ALKG1202R, respectively. ALK-IN-22 down-regulated the phosphorylation of ALK and its downstream proteins. ALK-IN-22 induces apoptosis. ALK-IN-22 can be […]

For research use only. We do not sell to patients. PI3K/AKT-IN-1 Biological Activity：PI3K/AKT-IN-1 is an effective PI3K/AKT dual inhibitor (IC50 of 6.99, 4.01 and 3.36 μM for PI3Kγ, PI3Kδ and AKT, respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis. Research Area：Cancer Targets：Akt|Apoptosis|PI3K Related Small Molecules:Physalin A;Bomedemstat […]

For research use only. We do not sell to patients. Crustecdysone CAS No. : 5289-74-7 Biological Activity：Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or […]