Tag: Inhibitor|Inducer

For research use only. We do not sell to patients. Larotrectinib sulfate CAS No. : 1223405-08-0 Biological Activity：Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C). Research Area：Cancer Targets：Trk Receptor|Apoptosis Related […]

For research use only. We do not sell to patients. ATH686 CAS No. : 853299-52-2 Biological Activity：ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects. Research Area：Cancer […]

For research use only. We do not sell to patients. Pexidartinib hydrochloride CAS No. : 2040295-03-0 Biological Activity：Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity […]

For research use only. We do not sell to patients. SGI-1027 CAS No. : 1020149-73-8 Biological Activity：SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate. Research Area：Cancer Targets：DNA Methyltransferase|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound […]

For research use only. We do not sell to patients. LDC000067 CAS No. : 1073485-20-7 Biological Activity：LDC000067 is a highly specific CDK9 inhibitor with an IC50 value of 44±10 nM in vitro. Research Area：Cancer Targets：CDK|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Anti-Breast Cancer Compound […]

For research use only. We do not sell to patients. HDAC10-IN-1 Biological Activity：HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells. Research Area：Cancer Targets：Autophagy|HDAC Related Small Molecules:Pivanex;Crotonoside;MPT0B390;RSC133;HDAC1/6-IN-1;HDAC/HSP90-IN-4;JPS014;HDAC-IN-4;HDAC-IN-27;1-Alaninechlamydocin;SKLB-23bb;Tacedinaline;HPOB;HDAC-IN-28;CG347B;Tubacin;HDAC6-IN-6;Resminostat;Alteminostat;HDAC-IN-47;Ivaltinostat formic;Crebinostat;FNDR-20123 free base;UF010;Homobutein;Ac-Lys-AMC;HDACs/mTOR Inhibitor 1;BRD73954 Trending products：Recombinant Proteins  |  […]

For research use only. We do not sell to patients. Alteminostat CAS No. : 1246374-97-9 Biological Activity：Alteminostat (CKD-581) is a potent HDAC inhibitor. Alteminostat inhibits the class I-II HDAC family via histone H3 and tubulin acetylation. Alteminostat can be used for lymphoma and multiple myeloma research. Research Area：Cancer Targets：HDAC|Apoptosis Related Screening Libraries:Clinical Compound Library Plus;Bioactive […]

For research use only. We do not sell to patients. hCAIX-IN-12 CAS No. : 2414598-85-7 Biological Activity：hCAIX-IN-12 is a potent hCAIX inhibitor with IC50 values of 0.74, 10.78 µM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer […]

For research use only. We do not sell to patients. Triclosan-d3 CAS No. : 1020719-98-5 Biological Activity：Triclosan D3 is the deuterium labeled Triclosan. Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, toys, and surgical cleaning treatments[2]. Research Area：Infection|Cancer Targets：Fungal|Autophagy|Bacterial|Antibiotic Related Small Molecules:Antifungal agent 20;Sandramycin;LLO (91-99);Gepotidacin;Oritavancin;Monascorubrin;Azlocillin sodium salt;Herbimycin A;Antibacterial agent […]

For research use only. We do not sell to patients. BI-847325 CAS No. : 1207293-36-4 Biological Activity：BI-847325 is an ATP competitive dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. Research Area：Cancer Targets：MEK|Aurora Kinase|Apoptosis Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library […]