Tag: Inhibitor|Antagonist

For research use only. We do not sell to patients. Ranitidine-d6 hydrochloride CAS No. : 1185238-09-8 Biological Activity：Ranitidine-d6 hydrochloride is the deuterium labeled Ranitidine hydrochloride. Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 […]

For research use only. We do not sell to patients. 3′,4′-Dimethoxyflavone CAS No. : 4143-62-8 Biological Activity：3′,4′-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3′,4′-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3′,4′-Dimethoxyflavone is also an aryl hydrocarbon […]

For research use only. We do not sell to patients. TAK-220 CAS No. : 333994-00-6 Biological Activity：TAK-220 is a selective and orally bioavailable CCR5 antagonist, with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, […]

For research use only. We do not sell to patients. Mecamylamine CAS No. : 60-40-2 Biological Activity：Mecamylamine is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine is also a ganglionic blocker. Mecamylamine can across the blood-brain barrier. Mecamylamine can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area[2][5]. Research Area：Neurological Disease|Cardiovascular Disease Targets：nAChR|Histamine […]

For research use only. We do not sell to patients. Doxepin D3 Hydrochloride CAS No. : 347840-07-7 Biological Activity：Doxepin D3 Hydrochloride is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and […]

For research use only. We do not sell to patients. Talampanel CAS No. : 161832-65-1 Biological Activity：Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models[2]. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain[2]. Research Area：Neurological Disease|Cancer Targets：Apoptosis|iGluR Related Screening Libraries:Drug Repurposing […]

For research use only. We do not sell to patients. Conessine CAS No. : 546-06-5 Biological Activity：Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity. Research Area：Infection Targets：Parasite|Histamine Receptor […]

For research use only. We do not sell to patients. PPADS tetrasodium CAS No. : 192575-19-2 Biological Activity：PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS […]

For research use only. We do not sell to patients. Rintodestrant CAS No. : 2088518-51-6 Biological Activity：Rintodestrant (G1T48) is an orally active, non-steroidal and selective estrogen receptor degrader. Rintodestrant (G1T48) is also a CDK4/6 inhibitor. Research Area：Cancer Targets：CDK|Estrogen Receptor/ERR Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound […]

For research use only. We do not sell to patients. KIRA9 Biological Activity：KIRA9 is a potent IRE1 inhibitor (IC50=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis. Research Area：Others Targets：IRE1|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant […]