Tag: Inhibitor|Antagonist

For research use only. We do not sell to patients. hA2A/hCA XII modulator 1 CAS No. : 2548963-55-7 Biological Activity：hA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent […]

For research use only. We do not sell to patients. Indophagolin CAS No. : 1207660-00-1 Biological Activity：Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 […]

For research use only. We do not sell to patients. PDE4-IN-4 CAS No. : 1793069-00-7 Biological Activity：PDE4-IN-4 is a dual M3 (pIC50 = 10.2) antagonist-PDE4 (pIC50 = 8.8) inhibitor for the inhaled treatment of pulmonary diseases. Research Area：Others Targets：Phosphodiesterase (PDE)|mAChR Related Small Molecules:VU0357017 hydrochloride;Senazodan hydrochloride;(E/Z)-HA155;Enpp/Carbonic anhydrase-IN-1;ATX inhibitor 22;Carbazeran citrate;TBPB;Imidafenacin;Bay 60-7550;BC11-38;Sabcomeline;Deltarasin hydrochloride;Glaucine;MK-6884;Brompheniramine-d6 maleate;Ziritaxestat;Udenafil-d7;D159687;ITI-214;PDE10-IN-5;Navafenterol saccharinate;ICI 153110;Furamidine dihydrochloride […]

For research use only. We do not sell to patients. Sparstolonin B CAS No. : 1259330-61-4 Biological Activity：Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities[2]. Research Area：Cancer|Infection|Inflammation/Immunology Targets：HIV|Toll-like Receptor (TLR) Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Immunology/Inflammation […]

For research use only. We do not sell to patients. Verapamil CAS No. : 52-53-9 Biological Activity：Verapamil ((±)-Verapamil) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil also inhibits CYP3A4. Verapamil has the potential for high blood pressure, heart arrhythmias and angina research[2][3]. Research Area：Metabolic Disease Targets：Calcium Channel|P-glycoprotein|Cytochrome […]

For research use only. We do not sell to patients. Bopindolol (malonate) CAS No. : 82857-38-3 Biological Activity：Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as […]

For research use only. We do not sell to patients. MMPSI CAS No. : 220509-74-0 Biological Activity：MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in […]

For research use only. We do not sell to patients. Sulfisoxazole diethanolamine CAS No. : 4299-60-9 Biological Activity：Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine […]

For research use only. We do not sell to patients. Chlorprothixene hydrochloride CAS No. : 6469-93-8 Biological Activity：Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity. Research Area：Neurological Disease Targets：Dopamine […]

For research use only. We do not sell to patients. Sigma-1 receptor antagonist 3 CAS No. : 1639220-17-9 Biological Activity：Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 […]