Tag: Inhibitor|Antagonist

For research use only. We do not sell to patients. Rimonabant-d10 hydrochloride CAS No. : 1044909-61-6 Biological Activity：Rimonabant-d10 (SR 141716A-d10) hydrochloride is the deuterium labeled Rimonabant hydrochloride. Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also […]

For research use only. We do not sell to patients. D4-abiraterone CAS No. : 154229-21-7 Biological Activity：D4-abiraterone is a major metabolite of abiraterone. D4-abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid-5a-reductase (SRD5A) and also an antagonist of androgen receptor. Research Area：Cancer Targets：Androgen Receptor|Cytochrome P450 Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. (Rac)-Zevaquenabant CAS No. : 1610420-28-4 Biological Activity：(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a cannabinoid receptor type 1 (CB1R)/iNOS antagonist, with a Ki of 5.7 nM for CB1R. (Rac)-Zevaquenabant is potential for the research of liver fibrosis. Research Area：Others Targets：NO Synthase|Cannabinoid Receptor Related Screening Libraries:Bioactive Compound Library […]

For research use only. We do not sell to patients. Doxofylline CAS No. : 69975-86-6 Biological Activity：Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, […]

For research use only. We do not sell to patients. Nogalamycin CAS No. : 1404-15-5 Biological Activity：Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin […]

For research use only. We do not sell to patients. Trimipramine CAS No. : 739-71-9 Biological Activity：Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, […]

For research use only. We do not sell to patients. Fluphenazine CAS No. : 69-23-8 Biological Activity：Fluphenazine is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine blocks neuronal voltage-gated sodium channels. Fluphenazine acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine can antagonize Methylphenidate-induced stereotyped gnawing and […]

For research use only. We do not sell to patients. Asimilobine CAS No. : 6871-21-2 Biological Activity：Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. Asimilobine is a dopamine biosynthesis inhibitor and a serotonergic receptor antagonist. Asimilobine shows an antimalarial and anti-cancer activity[2]. Research Area：Cancer|Infection Targets：Parasite|Dopamine Receptor|5-HT Receptor Related Small […]

For research use only. We do not sell to patients. Reltecimod CAS No. : 1447799-33-8 Biological Activity：Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, […]

For research use only. We do not sell to patients. Angiotensin (1-7) (acetate) Biological Activity：Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acetate acts […]