Tag: Inhibitor|Antagonist

For research use only. We do not sell to patients. 5-HT6/7 antagonist 1 CAS No. : 131999-28-5 Biological Activity：5-HT6/7 antagonist 1 is a multifunctional ligand that antagonizes 5-HT6/7/2A and D2 receptors, without interacting with M1 receptors and hERG channels. Targets：Dopamine Receptor|5-HT Receptor Related Small Molecules:F 13714;Alizapride hydrochloride;Thioproperazine;Mosapride-d5;Bromopride-d3;Nuciferine;Glaucine;Renzapride;SB-277011 dihydrochloride;LY 344864 racemate;Harmine hydrochloride;MIF-1 TFA;Valerenic acid;Arotinolol;Sulpiride;(Rac)-Razpipadon;Melitracen-d6 hydrochloride;Clebopride malate;WAY-100635;Nelotanserin;Flupentixol-d4 […]

For research use only. We do not sell to patients. Fenspiride CAS No. : 5053-06-5 Biological Activity：Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can […]

For research use only. We do not sell to patients. Verapamil hydrochloride CAS No. : 152-11-4 Biological Activity：Verapamil hydrochloride ((±)-Verapamil hydrochloride) is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. Verapamil hydrochloride also inhibits CYP3A4. Verapamil hydrochloride has the potential for high blood pressure, heart arrhythmias and angina research[2][3]. […]

For research use only. We do not sell to patients. Loxapine hydrochloride CAS No. : 54810-23-0 Biological Activity：Loxapine hydrochloride is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent[4]. Research Area：Neurological Disease Targets：Dopamine Receptor|5-HT Receptor Related Small Molecules:F 13714;Alizapride hydrochloride;Thioproperazine;Mosapride-d5;Bromopride-d3;Nuciferine;Glaucine;Renzapride;SB-277011 dihydrochloride;LY 344864 racemate;Harmine hydrochloride;MIF-1 TFA;Valerenic acid;Arotinolol;Sulpiride;(Rac)-Razpipadon;Melitracen-d6 hydrochloride;Clebopride malate;WAY-100635;Nelotanserin;Flupentixol-d4 dihydrochloride Trending […]

For research use only. We do not sell to patients. SM-1295 CAS No. : 1562375-46-5 Biological Activity：SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively[2]. Research Area：Cancer Targets：IAP|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:Physalin A;Bomedemstat […]

For research use only. We do not sell to patients. α-Spinasterol CAS No. : 481-18-5 Biological Activity：α-Spinasterol, isolated from Melandrium firmum, has antibacterial activity. α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, […]

For research use only. We do not sell to patients. Methdilazine CAS No. : 1982-37-2 Biological Activity：Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[2]. Research Area：Infection Targets：Histamine Receptor|Bacterial|Antibiotic Related […]

For research use only. We do not sell to patients. Proxalutamide CAS No. : 1398046-21-3 Biological Activity：Proxalutamide (GT0918) is an orally active potent androgen receptor (AR) antagonist. Proxalutamide (GT0918) can be used in the study for prostate cancer and COVID-19[2][3][4][5]. Research Area：Cancer Targets：Androgen Receptor|SARS-CoV Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. BMS-819881 CAS No. : 1197420-05-5 Biological Activity：BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC50 of 13 μM. Research Area：Metabolic Disease|Endocrinology Targets：MCHR1 (GPR24)|Cytochrome […]

For research use only. We do not sell to patients. Flunarizine dihydrochloride CAS No. : 30484-77-6 Biological Activity：Flunarizine dihydrochloride is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine dihydrochloride is a D2 dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects[2][3][4][5]. Research Area：Neurological Disease Targets：Dopamine Receptor|Calcium Channel|Sodium Channel Related Screening […]