Tag: Inhibitor|Antagonist

For research use only. We do not sell to patients. Plerixafor-d4 CAS No. : 1246819-87-3 Biological Activity：Plerixafor-d4 is the deuterium labeled Plerixafor. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 […]

For research use only. We do not sell to patients. Propiverine hydrochloride CAS No. : 54556-98-8 Biological Activity：Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[2]. Research Area：Neurological Disease Targets：Calcium Channel|mAChR Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. H3R antagonist 2 Biological Activity：H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor (H3R) antagonist with a Ki of 170 nM for hH3R . H3R antagonist 2 shows inhibitory effects with IC50 values of 180, 880 and 775 nM for acetylcholinesterase, butyrylcholinesterase and […]

For research use only. We do not sell to patients. PCS1055 dihydrochloride CAS No. : 361979-40-0 Biological Activity：PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC50 of 18.1 nM and a Kd of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [3H]-NMS binding to the M4 receptor with a Ki of […]

For research use only. We do not sell to patients. Ginsenoside Ro CAS No. : 34367-04-9 Biological Activity：Ginsenoside Ro (Polysciasaponin P3; Chikusetsusaponin 5; Chikusetsusaponin V) exhibits a Ca2+-antagonistic antiplatelet effect with an IC50 of 155  μM. Ginsenoside Ro reduces the production of TXA2 more than it reduces the activities of COX-1 and TXAS. Research Area：Cardiovascular […]

For research use only. We do not sell to patients. Itopride CAS No. : 122898-67-3 Biological Activity：Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be […]

For research use only. We do not sell to patients. Sulfisoxazole CAS No. : 127-69-5 Biological Activity：Sulfisoxazole (Sulfafurazole) is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome […]

For research use only. We do not sell to patients. Methdilazine hydrochloride CAS No. : 1229-35-2 Biological Activity：Methdilazine hydrochloride is an orally active antibiotic (histamine antagonist). Methdilazine hydrochloride can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[2]. Research Area：Infection […]

For research use only. We do not sell to patients. KN-62 CAS No. : 127191-97-3 Biological Activity：KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a Ki of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at P2X7 […]

For research use only. We do not sell to patients. NF279 CAS No. : 202983-32-2 Biological Activity：NF279 is a potent selective and reversible P2X1 receptor antagonist, with an IC50 of 19 nM. NF279 displays good selectivity over P2X2, P2X3 (IC50=1.62 μM), P2X4 (IC50>300 μM). NF279 is a dual HIV-1 coreceptor inhibitor that interferes with the […]