Tag: Inhibitor|Antagonist

For research use only. We do not sell to patients. MRS 1523 CAS No. : 212329-37-8 Biological Activity：MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs […]

For research use only. We do not sell to patients. Ranitidine CAS No. : 66357-35-5 Biological Activity：Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine is a weak inhibitor of CYP2C19 and CYP2C9[2]. Research Area：Infection|Endocrinology|Metabolic Disease|Cancer Targets：Histamine Receptor|Bacterial|Cytochrome P450 Related Small Molecules:Sandramycin;LLO […]

For research use only. We do not sell to patients. 5-HT6R/MAO-B modulator 1 Biological Activity：5-HT6R/MAO-B modulator 1 (compound 48) is an antagonist of 5-HT6R at Gs signaling and an irreversible MAO-B inhibitor. 5-HT6R/MAO-B modulator 1 exhibits glioprotective properties. 5-HT6R/MAO-B modulator 1 can reverse Scopolamine-induced memory deficits. Research Area：Neurological Disease Targets：5-HT Receptor|Monoamine Oxidase Related Small Molecules:F […]

For research use only. We do not sell to patients. Glicoricone CAS No. : 161099-37-2 Biological Activity：Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC50 of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity[2]. Research Area：Metabolic Disease […]

For research use only. We do not sell to patients. Mecamylamine hydrochloride CAS No. : 826-39-1 Biological Activity：Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area[2][5]. […]

For research use only. We do not sell to patients. Trimipramine maleate CAS No. : 521-78-8 Biological Activity：Trimipramine maleate is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic […]

For research use only. We do not sell to patients. TD-0212 CAS No. : 1073549-10-6 Biological Activity：TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP. Research Area：Inflammation/Immunology|Endocrinology Targets：Angiotensin Receptor|Neprilysin Related […]

For research use only. We do not sell to patients. Azelastine hydrochloride CAS No. : 79307-93-0 Biological Activity：Azelastine hydrochloridem, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine hydrochloride can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[2][3][4]. Research Area：Infection|Endocrinology|Metabolic Disease|Inflammation/Immunology Targets：Histamine Receptor|SARS-CoV Related Screening Libraries:Drug Repurposing […]

For research use only. We do not sell to patients. Ifenprodil tartrate CAS No. : 23210-58-4 Biological Activity：Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM). Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal […]

For research use only. We do not sell to patients. IT1t dihydrochloride CAS No. : 1092776-63-0 Biological Activity：IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. Research Area：Inflammation/Immunology|Endocrinology|Cancer Targets：CXCR|HIV Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Antiviral Compound Library;Small Molecule Immuno-Oncology […]