Tag: Inhibitor|Activator|Inducer

For research use only. We do not sell to patients. Mangiferin CAS No. : 4773-96-0 Biological Activity：Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities[2][3]. Research Area：Cancer Targets：Keap1-Nrf2|NF-κB|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound […]

For research use only. We do not sell to patients. Lapatinib tosylate CAS No. : 1187538-35-7 Biological Activity：Lapatinib (GW572016) tosylate is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. Research Area：Cancer Targets：EGFR|Ferroptosis|Autophagy Related Small Molecules:CIL56;DB0614;NSC81111;pp60 (v-SRC) […]

For research use only. We do not sell to patients. Alantolactone CAS No. : 546-43-0 Biological Activity：Alantolactone is a selective STAT3 inhibitor, with potent anticancer activity. Alantolactone induces apoptosis in cancer[2][3]. Research Area：Cancer Targets：STAT|TGF-beta/Smad|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Stem Cell […]

For research use only. We do not sell to patients. Lapatinib-d7 ditosylate CAS No. : 1009307-24-7 Biological Activity：Lapatinib-d7 (GW572016-d7) ditosylate is the deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[2]. Research Area：Cancer […]

For research use only. We do not sell to patients. Adezmapimod hydrochloride CAS No. : 869185-85-3 Biological Activity：Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than […]

For research use only. We do not sell to patients. Jaceosidin CAS No. : 18085-97-7 Biological Activity：Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin exhibits anti-cancer[2], anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation[3]. Research […]

For research use only. We do not sell to patients. RA375 Biological Activity：RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead. Research Area：Cancer Targets：Reactive Oxygen […]

For research use only. We do not sell to patients. Phenoxodiol CAS No. : 81267-65-4 Biological Activity：Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell […]

For research use only. We do not sell to patients. Pregnenolone monosulfate-d4 sodium CAS No. : 1485492-21-4 Biological Activity：Pregnenolone monosulfate-d4 (sodium) is the deuterium labeled Pregnenolone monosulfate. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor […]

For research use only. We do not sell to patients. Lapatinib-d4-1 CAS No. : 1184264-15-0 Biological Activity：Lapatinib-d4-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. Research Area：Cancer Targets：EGFR|Ferroptosis|Autophagy Related Small Molecules:CIL56;DB0614;NSC81111;pp60 […]