Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Tetrahydrocurcumin D6 CAS No. : 1794898-13-7 Biological Activity：Tetrahydrocurcumin D6 (HZIV 81-2 D6) is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin is a Curcuminoid which displays inhibitory activity for CYP2C9 and CYP3A4. Research Area：Cancer|Inflammation/Immunology Targets：Autophagy|Cytochrome P450 Related Small Molecules:SR9186;AMG-208;CYP1B1-IN-1;CYP2C9/CYP2C19-IN-1;Hypericin;Galeterone;Ranitidine;Bergapten;Ginsenoside Rd;AS1810722;Isoglycycoumarin;Polygalaxanthone III;Phenyltoloxamine;Ezutromid;Seviteronel;β-​Apo-​8′-​carotenal;Diosmetin-d3;EDP-305;Fipronil;Cholesterol 24-hydroxylase-IN-1;TMS;Harmalol hydrochloride;Olivetol Trending products：Recombinant Proteins  |  Bioactive […]

For research use only. We do not sell to patients. Vinblastine sulfate CAS No. : 143-67-9 Biological Activity：Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM. Research Area：Cancer Targets：Autophagy|Microtubule/Tubulin Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound […]

For research use only. We do not sell to patients. KY-05009 CAS No. : 1228280-29-2 Biological Activity：KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of […]

For research use only. We do not sell to patients. Demethyleneberberine CAS No. : 25459-91-0 Biological Activity：Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting NF-κB pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease […]

For research use only. We do not sell to patients. Nampt-IN-3 CAS No. : 2121591-52-2 Biological Activity：Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. Research Area：Cancer Targets：Autophagy|HDAC|NAMPT|Apoptosis Related Screening Libraries:Bioactive Compound […]

For research use only. We do not sell to patients. Gypenoside LI CAS No. : 94987-10-7 Biological Activity：Gypenoside LI, a gypenoside monomer, possesses anti-tumor activity. Gypenoside LI induces cell apoptosis, cell cycle and migration[2]. Research Area：Cancer Targets：MicroRNA|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Natural Product Library;Anti-Cancer Compound Library;Glycoside Compound […]

For research use only. We do not sell to patients. Parthenolide CAS No. : 20554-84-1 Biological Activity：Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs. Research Area：Cancer Targets：Autophagy|NF-κB|Mitophagy|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Natural Product […]

For research use only. We do not sell to patients. Garcinone C CAS No. : 76996-27-5 Biological Activity：Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of […]

For research use only. We do not sell to patients. Amiloride hydrochloride CAS No. : 2016-88-8 Biological Activity：Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2[3]) channel. Research Area：Metabolic Disease|Cardiovascular Disease Targets：TRP Channel|Sodium Channel|Apoptosis Related Screening […]

For research use only. We do not sell to patients. PHA-665752 CAS No. : 477575-56-7 Biological Activity：PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase (Ki=4 nM; IC50=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and […]