Tag: Inhibitor|Activator

For research use only. We do not sell to patients. FTI-277 CAS No. : 170006-73-2 Biological Activity：FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 can inhibit hepatitis delta virus (HDV) infection. Research Area：Cancer|Infection Targets：Farnesyl Transferase|Apoptosis|Ras Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic […]

For research use only. We do not sell to patients. DIF-3 CAS No. : 113411-17-9 Biological Activity：DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell […]

For research use only. We do not sell to patients. Cilostazol CAS No. : 73963-72-1 Biological Activity：Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM[2]. Research Area：Cardiovascular Disease|Cancer Targets：Phosphodiesterase (PDE)|Autophagy Related Screening Libraries:Drug Repurposing Compound Library […]

For research use only. We do not sell to patients. PT4 CAS No. : 1280738-47-7 Biological Activity：PT4 is a therapeutic agent against Cutaneous leishmaniasis (CL). PT4 is effective against both species of Leishmania, with IC50s of 125.18 and 233.18 μM for L. amazonensis and L. braziliensis, respectively. PT4 decreases of mitochondrial membrane potential and increases […]

For research use only. We do not sell to patients. Nevanimibe hydrochloride CAS No. : 133825-81-7 Biological Activity：Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and […]

For research use only. We do not sell to patients. TM5441 CAS No. : 1190221-43-2 Biological Activity：TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[2]. […]

For research use only. We do not sell to patients. Tomatine CAS No. : 17406-45-0 Biological Activity：Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome […]

For research use only. We do not sell to patients. hnRNPK-IN-1 CAS No. : 2313528-04-8 Biological Activity：hnRNPK-IN-1 is a heterogeneous nuclear ribonucleoprotein K (hnRNPK) binding ligand with Kd values of 4.6 μM and 2.6 μM measured with SPR and MST, respectively. hnRNPK-IN-1 inhibits c-myc transcription by disrupting the binding of hnRNPK and c-myc promoter. hnRNPK-IN-1 […]

For research use only. We do not sell to patients. Bromhexine hydrochloride CAS No. : 611-75-6 Biological Activity：Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and […]

For research use only. We do not sell to patients. Skatole CAS No. : 83-34-1 Biological Activity：Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Research Area：Others Targets：Fungal|Autophagy|p38 MAPK|Bacterial|Endogenous Metabolite|Aryl Hydrocarbon Receptor Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor […]