Tag: Inhibitor|Activator

For research use only. We do not sell to patients. PF-573228 CAS No. : 869288-64-2 Biological Activity：PF-573228 is a potent and selective FAK inhibitor with IC50 of 4 nM for purified recombinant catalytic fragment of FAK. Research Area：Cancer Targets：FAK|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library; […]

For research use only. We do not sell to patients. Taltobulin hydrochloride Biological Activity：Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin hydrochloride inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, […]

For research use only. We do not sell to patients. Chrysosplenetin CAS No. : 603-56-5 Biological Activity：Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma […]

For research use only. We do not sell to patients. HG-7-85-01 CAS No. : 1258391-13-7 Biological Activity：HG-7-85-01 is a type II ATP competitive inhibitor of wild-type and gatekeeper mutations forms of Bcr-Abl, PDGFRα, Kit, and Src kinases. HG-7-85-01 inhibits T315I mutant Bcr-Abl kinase, KDR and RET with IC50s of 3 nM, 20 nM and 30 […]

For research use only. We do not sell to patients. JG-98 CAS No. : 1456551-16-8 Biological Activity：JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages[2][3]. Research Area：Cancer Targets：HSP|Apoptosis Related Screening […]

For research use only. We do not sell to patients. Enoxacin-d8 hydrochloride Biological Activity：Enoxacin-d8 (hydrochloride) is deuterium labeled Enoxacin. Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis […]

For research use only. We do not sell to patients. Halofuginone hydrobromide CAS No. : 64924-67-0 Biological Activity：Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[2]. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone […]

For research use only. We do not sell to patients. D4476 CAS No. : 301836-43-1 Biological Activity：D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1(CK1) with an IC50 value of 0.3 μM in vitro. Research Area：Cancer Targets：Autophagy|Casein Kinase|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Stem […]

For research use only. We do not sell to patients. MIR96-IN-1 CAS No. : 1311982-88-3 Biological Activity：MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM […]

For research use only. We do not sell to patients. Famitinib CAS No. : 1044040-56-3 Biological Activity：Famitinib (SHR1020), an orally active multi-targeted kinase inhibitor, inhibits the activity of c-kit, VEGFR-2 and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM and 6.6 nM, respectively. Famitinib exerts powerful antitumor activity in human gastric cancer cells and […]