Tag: Inhibitor|Activator

For research use only. We do not sell to patients. PARP14 inhibitor H10 CAS No. : 2084811-68-5 Biological Activity：PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis. Research Area：Cancer Targets：PARP|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus; […]

For research use only. We do not sell to patients. Tempo CAS No. : 2564-83-2 Biological Activity：Tempo is a classic nitroxide radical and is a selective scavenger of ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. […]

For research use only. We do not sell to patients. BRD3308 CAS No. : 1550053-02-5 Biological Activity：BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23-fold selectivity for HDAC3 over HDAC1 (IC50 of 1.26 μM) or HDAC2 (IC50 of 1.34 μM). BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory […]

For research use only. We do not sell to patients. Bosutinib D8 Biological Activity：Bosutinib D8 (SKI-606 D8) is a deuterium labeled Bosutinib. Bosutinib is a dual Src/Abl inhibitor with IC50s of 1.2 nM and 1 nM, respectively[2]. Research Area：Cancer Targets：Autophagy|Bcr-Abl|Src Related Small Molecules:KB SRC 4;Tirbanibulin dihydrochloride;AT9283;Bafetinib;Pivanex;p60c-src substrate II;SNIPER(ABL)-039;Flumatinib mesylate;IHMT-TRK-284;Caffeic acid-pYEEIE TFA;PP2;PP58;SNIPER(ABL)-049;Olverembatinib;ENMD-2076 Tartrate;CH6953755;GNF-2;CT-721;SNIPER(ABL)-015;GNF-5;Fenlean;TL02-59;BCR-ABL-IN-4;A-770041;SNIPER(ABL)-033;PF 477736;CHMFL-ABL-039;PD166326 Trending products：Recombinant […]

For research use only. We do not sell to patients. YS-49 CAS No. : 132836-42-1 Biological Activity：YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound […]

For research use only. We do not sell to patients. ONX-0914 CAS No. : 960374-59-8 Biological Activity：ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). […]

For research use only. We do not sell to patients. PD173074 CAS No. : 219580-11-7 Biological Activity：PD173074 is a potent FGFR1 inhibitor with an IC50 of 25 nM and also inhibits VEGFR2 with an IC50 of 100-200 nM, showing 1000-fold selectivity for FGFR1 over PDGFR and c-Src. Research Area：Cancer Targets：VEGFR|FGFR|Apoptosis Related Screening Libraries:Bioactive Compound Library […]

For research use only. We do not sell to patients. Carnosol CAS No. : 5957-80-2 Biological Activity：Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. Carnosol, a Nrf2 activator, increases the nuclear levels of Nrf2 and can promote the expression of […]

For research use only. We do not sell to patients. Camalexin CAS No. : 135531-86-1 Biological Activity：Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production[2][3]. Research Area：Cancer|Infection Targets：Fungal|Reactive Oxygen Species|Bacterial Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound […]

For research use only. We do not sell to patients. Cerivastatin CAS No. : 145599-86-6 Biological Activity：Cerivastatin is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin reduces low-density lipoprotein cholesterol levels. Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly […]