Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Dapivirine CAS No. : 244767-67-7 Biological Activity：Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations[2]. Research Area：Infection Targets：Autophagy|HIV|Apoptosis|Reverse […]

For research use only. We do not sell to patients. INCB-057643 CAS No. : 1820889-23-3 Biological Activity：INCB-057643 is a novel, orally bioavailable BET inhibitor. Research Area：Cancer Targets：Epigenetic Reader Domain|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Drug Repurposing […]

For research use only. We do not sell to patients. Mitoguazone CAS No. : 459-86-9 Biological Activity：Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in […]

For research use only. We do not sell to patients. SAR125844 CAS No. : 1116743-46-4 Biological Activity：SAR125844 is a potent, highly selective, reversible and ATP-competitive MET receptor tyrosine kinase (RTK) inhibitor, with an IC50 of 4.2 nM. Shows inhibition of MET autophosphorylation in cell-based assays. Research Area：Cancer Targets：c-Met/HGFR|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical […]

For research use only. We do not sell to patients. SS28 CAS No. : 141172-08-9 Biological Activity：SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin. Research Area：Cancer Targets：Microtubule/Tubulin|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Tirbanibulin dihydrochloride;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor […]

For research use only. We do not sell to patients. PIM447 CAS No. : 1210608-43-7 Biological Activity：PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis[2]. Research Area：Cancer […]

For research use only. We do not sell to patients. ABT-100 CAS No. : 450839-40-4 Biological Activity：ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, […]

For research use only. We do not sell to patients. Roxadustat CAS No. : 808118-40-3 Biological Activity：Roxadustat is an orally active hypoxia-inducible factor (HIF) prolyl-hydroxylase (PHD) inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin. Research Area：Cancer Targets：Ferroptosis|HIF/HIF Prolyl-Hydroxylase Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. PDK4-IN-1 CAS No. : 2310262-10-1 Biological Activity：PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer […]

For research use only. We do not sell to patients. Tandutinib CAS No. : 387867-13-2 Biological Activity：Tandutinib (MLN518) is a potent and selective inhibitor of the FLT3 with an IC50 of 0.22 μM, and also inhibits c-Kit and PDGFR with IC50s of 0.17 μM and 0.20 μM, respectively. Tandutinib can be used for acute myelogenous […]