Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Daphnoretin CAS No. : 2034-69-7 Biological Activity：Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity. Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst[2]. Research Area：Infection Targets：Influenza Virus|PKC Related Screening Libraries:Natural Product Library Plus;Bioactive […]

For research use only. We do not sell to patients. 4-Hydroxytolbutamide CAS No. : 5719-85-7 Biological Activity：4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[2]. Research Area：Cancer|Metabolic Disease Targets：Autophagy|Potassium Channel Related Small Molecules:Kv3 modulator 2;Brompheniramine-d6 maleate;Pinacidil;AMP-PNP tetralithium;IK1 […]

For research use only. We do not sell to patients. Vandetanib hydrochloride CAS No. : 524722-52-9 Biological Activity：Vandetanib hydrochloride (D6474 hydrochloride) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib hydrochloride also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM). Research Area：Cancer Targets：Autophagy|VEGFR|Apoptosis […]

For research use only. We do not sell to patients. Ruxolitinib sulfate CAS No. : 1092939-16-6 Biological Activity：Ruxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3. Research Area：Cancer Targets：JAK|Autophagy Related Small Molecules:AZ-3;JAK3/BTK-IN-1;AT9283;Benzene hexabromide;(E/Z)-Zotiraciclib;JAK-IN-10;Baricitinib-d3;JAK3-IN-6;Coumermycin A1;Deucravacitinib;Momelotinib-3,3,5,5-d4;SJ10542;Delgocitinib;Upadacitinib;α7 […]

For research use only. We do not sell to patients. Iprodione CAS No. : 36734-19-7 Biological Activity：Iprodione, a dicarboximide fungicide, has a highly specific action, with a capacity to cause oxidative damage through production of free oxygen radicals (ROS). Iprodione does not appear to be species selective. Research Area：Infection Targets：Fungal|Reactive Oxygen Species Related Screening Libraries:Bioactive […]

For research use only. We do not sell to patients. Masitinib mesylate CAS No. : 1048007-93-7 Biological Activity：Masitinib mesylate (AB-1010 mesylate) is a potent, orally bioavailable, and selective inhibitor of c-Kit (IC50=200 nM for human recombinant c-Kit). It also inhibits PDGFRα/β (IC50s=540/800 nM), Lyn (IC50= 510 nM for LynB), Lck, and, to a lesser extent, […]

For research use only. We do not sell to patients. KRAS inhibitor-9 CAS No. : 300809-71-6 Biological Activity：KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes […]

For research use only. We do not sell to patients. Tyrphostin AG1296 CAS No. : 146535-11-7 Biological Activity：Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell […]

For research use only. We do not sell to patients. Clofilium tosylate CAS No. : 92953-10-1 Biological Activity：Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent. Research Area：Cancer|Cardiovascular Disease Targets：Potassium Channel|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Membrane Transporter/Ion Channel Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. SC144 hydrochloride CAS No. : 917497-70-2 Biological Activity：SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows […]