Tag: Inhibitor|Activator

For research use only. We do not sell to patients. BIIB021 CAS No. : 848695-25-0 Biological Activity：BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively. Research Area：Cancer Targets：Autophagy|HSP Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. Sp-cAMPS CAS No. : 71774-13-5 Biological Activity：Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC50 of […]

For research use only. We do not sell to patients. PI-103 CAS No. : 371935-74-9 Biological Activity：PI-103 is a potent PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 also inhibits DNA-PK with an IC50 […]

For research use only. We do not sell to patients. Linopirdine CAS No. : 105431-72-9 Biological Activity：Linopirdine (DuP 996) is an orally active, selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor with an IC50 of 2.4 μM. Linopirdine is a TRPV1 agonist. Linopirdine, a putative cognition enhancing drug, increases acetylcholine release in rat brain […]

For research use only. We do not sell to patients. PARP/PI3K-IN-1 CAS No. : 2337386-47-5 Biological Activity：PARP/PI3K-IN-1 (compound 15) is a potent PARP/PI3K inhibitor with pIC50 values of 8.22, 8.44, 8.25, 6.54, 8.13, 6.08 for PARP-1, PARP-2, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively. PARP/PI3K-IN-1 is a highly effective anticancer compound targeted against a wide range […]

For research use only. We do not sell to patients. Ceranib-2 CAS No. : 1402830-75-4 Biological Activity：Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces […]

For research use only. We do not sell to patients. Pioglitazone-d4 CAS No. : 1134163-29-3 Biological Activity：Pioglitazone D4 (U 72107 D4) is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and […]

For research use only. We do not sell to patients. LY-411575 CAS No. : 209984-57-6 Biological Activity：LY-411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), and also inhibits Notch S3 cleavage with IC50 of 0.39 nM. Research Area：Neurological Disease Targets：Notch|γ-secretase|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Neuronal Signaling Compound Library;Stem […]

For research use only. We do not sell to patients. Diminazene aceturate CAS No. : 908-54-3 Biological Activity：Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites […]

For research use only. We do not sell to patients. Erastin CAS No. : 571203-78-6 Biological Activity：Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3). Research Area：Cancer Targets：Ferroptosis|VDAC Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:CIL56;DB0614;Ciclopirox-d11;Ciclopirox olamine;Curcumin;(-)-Epicatechin;Eugenol-d3;Artemisinin-d3;MMRi62;UAMC-3203;L-Glutamic acid-15N,d5;Chalcones A-N-5;Pifithrin-β hydrobromide;PD146176;Roxadustat;Matrine;Liproxstatin-1;Hemin;L-Glutamic acid monosodium salt;Acetylcysteine-d3;Pifithrin-α hydrobromide Trending products：Recombinant Proteins  |  Bioactive Screening […]