Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Pitavastatin D4 CAS No. : 2070009-71-9 Biological Activity：Pitavastatin D4 (NK-104 D4) is deuterium labeled Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor. Research Area：Cancer|Metabolic Disease Targets：Autophagy|Mitophagy|HMG-CoA Reductase (HMGCR)|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;Curcumin;STAT3-IN-10 Trending products：Recombinant Proteins  […]

For research use only. We do not sell to patients. Roquefortine C CAS No. : 58735-64-1 Biological Activity：Roquefortine C, a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins. Roquefortine C has bacteriostatic activities against Gram-positive bacteria. Research Area：Cancer|Infection Targets：Bacterial|P-glycoprotein|Endogenous Metabolite|Cytochrome P450 Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;2-Mercaptobenzothiazole;Sandramycin;LLO […]

For research use only. We do not sell to patients. Agrimol B CAS No. : 55576-66-4 Biological Activity：Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, […]

For research use only. We do not sell to patients. Praelolide Biological Activity：Praelolide is a potent Nrf2 activator. Praelolide suppresses osteoclastogenesis and reactive oxygen species (ROS) production. Praelolide disrupts Keap1-Nrf2 protein-protein interactions by noncovalent binding to Keap1. Praelolide has the potential for the research of osteoclastogenic bone disease. Research Area：Metabolic Disease Targets：Keap1-Nrf2|NF-κB Related Small Molecules:Akt/NF-κB/JNK-IN-1;Icariside […]

For research use only. We do not sell to patients. PF-543 hydrochloride CAS No. : 1706522-79-3 Biological Activity：PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. […]

For research use only. We do not sell to patients. LY 303511 CAS No. : 154447-38-8 Biological Activity：LY303511 is a structural analogue of LY294002. LY303511 does not inhibit PI3K. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells. LY303511 reversibly blocks K+ currents (IC50=64.6±9.1 μM) in MIN6 insulinoma cells. Research Area：Cancer Targets：TNF Receptor|Potassium Channel Related Small […]

For research use only. We do not sell to patients. Voreloxin Hydrochloride CAS No. : 175519-16-1 Biological Activity：Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis. Research Area：Cancer Targets：Topoisomerase|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus; Related Small […]

For research use only. We do not sell to patients. CGP 57380 CAS No. : 522629-08-9 Biological Activity：CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Research Area：Cancer Targets：MNK|Apoptosis Related Screening […]

For research use only. We do not sell to patients. Peretinoin CAS No. : 81485-25-8 Biological Activity：Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro […]

For research use only. We do not sell to patients. Rasagiline mesylate CAS No. : 161735-79-1 Biological Activity：Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively. Research Area：Neurological Disease Targets：Autophagy|Monoamine Oxidase|Apoptosis Related Screening Libraries:Covalent Screening […]