Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Phloracetophenone CAS No. : 480-66-0 Biological Activity：Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity. Phloracetophenone stimulats bile secretion mediated through Mrp2[2]. Research Area：Infection|Metabolic Disease Targets：Bacterial|Antibiotic|Cytochrome P450 Related Screening Libraries:Natural Product […]

For research use only. We do not sell to patients. NVP-ADW742 CAS No. : 475488-23-4 Biological Activity：NVP-ADW742 (ADW742) is an orally active, selective IGF-1R tyrosine kinase inhibitor with an IC50 of 0.17 μM. NVP-ADW742 inhibits insulin receptor (InsR) with an IC50 of 2.8 μM. NVP-ADW742 induces pleiotropic antiproliferative/proapoptotic biologic sequelae in tumor cells[2]. Research Area：Cancer|Endocrinology […]

For research use only. We do not sell to patients. Artesunate CAS No. : 88495-63-0 Biological Activity：Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1). Research Area：Cancer Targets：Parasite|Ferroptosis|STAT|Virus Protease Related Screening Libraries:Covalent Screening Library Plus;Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound […]

For research use only. We do not sell to patients. LY2857785 CAS No. : 1619903-54-6 Biological Activity：LY2857785 is a type I reversible and competitive ATP kinase inhibitor against CDK9 (IC50 11 nM) and other transcription kinases CDK8 (IC50 16 nM), and CDK7 (IC50 246 nM). Research Area：Cancer Targets：CDK|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound […]

For research use only. We do not sell to patients. KEA1-97 CAS No. : 2138882-71-8 Biological Activity：KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity. Research Area：Cancer Targets：Caspase|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. Cerivastatin sodium CAS No. : 143201-11-0 Biological Activity：Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness […]

For research use only. We do not sell to patients. Bempedoic acid CAS No. : 738606-46-7 Biological Activity：Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor. Bempedoic acid (ETC-1002) activates AMPK[2]. Research Area：Metabolic Disease Targets：ATP Citrate Lyase|AMPK Related Screening Libraries:Natural Product-like Compound Library;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library […]

For research use only. We do not sell to patients. Nerol CAS No. : 106-25-2 Biological Activity：Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca2+ and ROS. Antifungal activity[2]. Research Area：Infection Targets：Fungal|Reactive Oxygen Species|Endogenous Metabolite|Apoptosis|Mitochondrial Metabolism Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection […]

For research use only. We do not sell to patients. Samotolisib CAS No. : 1386874-06-1 Biological Activity：Samotolisib (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. Samotolisib […]

For research use only. We do not sell to patients. L-685458 CAS No. : 292632-98-5 Biological Activity：L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 […]