Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Cilengitide TFA CAS No. : 199807-35-7 Biological Activity：Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively. Research Area：Cancer Targets：Integrin|Autophagy Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library […]

For research use only. We do not sell to patients. HIOC CAS No. : 314054-36-9 Biological Activity：HIOC is a potent and selective activator of TrkB (tropomyosin related kinase B) receptor. HIOC can pass the blood-brain and blood-retinal barriers.HIOC activates TrkB/ERK pathway and decreases neuronal cell apoptosis. HIOC attenuates early brain injury after SAH (subarachnoid hemorrhage). […]

For research use only. We do not sell to patients. GPP78 CAS No. : 1202580-59-3 Biological Activity：GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has […]

For research use only. We do not sell to patients. Dihydroartemisinic acid CAS No. : 85031-59-0 Biological Activity：Dihydroartemisinic acid (Dihydroqinghao acid) is a biosynthetic precursor to the antimalarial agent Artemisinin. Research Area：Infection Targets：Parasite|Ferroptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Natural Product Library;Ferroptosis Compound Library;Terpenoids Library;Traditional Chinese Medicine Active Compound […]

For research use only. We do not sell to patients. Diphenyleneiodonium chloride CAS No. : 4673-26-1 Biological Activity：Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species. Research Area：Inflammation/Immunology|Neurological Disease Targets：Reactive Oxygen Species|NADPH Oxidase|TRP […]

For research use only. We do not sell to patients. ELR510444 CAS No. : 1233948-35-0 Biological Activity：ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines. IC50 value: 30.9 nM(MDA-MB-231 cell) [1] Target: Microtubule disruptor […]

For research use only. We do not sell to patients. WP1066 CAS No. : 857064-38-1 Biological Activity：WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3. Research Area：Cancer Targets：JAK|STAT|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound […]

For research use only. We do not sell to patients. SC99 CAS No. : 882290-02-0 Biological Activity：SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits […]

For research use only. We do not sell to patients. GSK1904529A CAS No. : 1089283-49-7 Biological Activity：GSK1904529A is a potent, selective, orally active, and ATP-competitive inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), with IC50s of 27 and 25 nM, respectively. GSK1904529A shows poor activity (IC50>1 μM) in 45 other serine/threonine and […]

For research use only. We do not sell to patients. 18α-Glycyrrhetinic acid CAS No. : 1449-05-4 Biological Activity：18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis[2]. Research Area：Cancer|Inflammation/Immunology|Neurological Disease Targets：NF-κB|Proteasome|Apoptosis Related Screening Libraries:Natural Product […]