Tag: Inhibitor|Activator

For research use only. We do not sell to patients. GSK-3β inhibitor 3 CAS No. : 1448990-73-5 Biological Activity：GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β), with an IC50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia. Research […]

For research use only. We do not sell to patients. BMS-202 CAS No. : 1675203-84-5 Biological Activity：BMS-202 is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 has antitumor activity[2]. Research Area：Cancer Targets：PD-1/PD-L1|Apoptosis Related Screening […]

For research use only. We do not sell to patients. Skatole-d8 CAS No. : 697807-03-7 Biological Activity：Skatole-d8 (3-Methylindole-d8) is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Research Area：Others Targets：Fungal|Autophagy|p38 MAPK|Bacterial|Endogenous Metabolite|Aryl Hydrocarbon Receptor Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Antifungal agent 20;Nicotinamide […]

For research use only. We do not sell to patients. Telaglenastat hydrochloride CAS No. : 1874231-60-3 Biological Activity：Telaglenastat (CB-839) hydrochloride is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and […]

For research use only. We do not sell to patients. rel-Zotatifin CAS No. : 2098191-54-7 Biological Activity：rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the […]

For research use only. We do not sell to patients. Vandetanib CAS No. : 443913-73-3 Biological Activity：Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM). Research Area：Cancer Targets：Autophagy|VEGFR|Apoptosis Related Screening Libraries:Drug Repurposing […]

For research use only. We do not sell to patients. G-749 CAS No. : 1457983-28-6 Biological Activity：G-749 is a potent, oral active and ATP competitive FLT3 inhibitor, with IC50s of 0.4 nM and 0.6 nM for FLT3 wild type and FLT3-D835Y, respectively. G-749 can be used for the research of drug resistance for acute myeloid […]

For research use only. We do not sell to patients. PFI-1 CAS No. : 1403764-72-6 Biological Activity：PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM in a cell-free assay. Research Area：Cancer Targets：Epigenetic Reader Domain|Autophagy|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound […]

For research use only. We do not sell to patients. Furanodiene CAS No. : 19912-61-9 Biological Activity：Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level. Research Area：Cancer Targets：Reactive […]

For research use only. We do not sell to patients. KU-57788 CAS No. : 503468-95-9 Biological Activity：KU-57788 (NU7441) is a highly potent and selective DNA-PK inhibitor with an IC50 of 14 nM. KU-57788 is an NHEJ pathway inhibitor. KU-57788 also inhibits PI3K and mTOR with IC50s of 5.0 and 1.7 μM, respectively. Research Area：Cancer Targets：CRISPR/Cas9|DNA-PK […]