Tag: Inhibitor|Activator

For research use only. We do not sell to patients. ONX-0914 TFA Biological Activity：ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). […]

For research use only. We do not sell to patients. Pioglitazone-d4 (alkyl) CAS No. : 1134163-31-7 Biological Activity：Pioglitazone-d4 (alkyl) (U 72107-d4 (alkyl)) is the deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human […]

For research use only. We do not sell to patients. Ginsenoside F4 CAS No. : 181225-33-2 Biological Activity：Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated […]

For research use only. We do not sell to patients. PI-103 Hydrochloride CAS No. : 371935-79-4 Biological Activity：PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK […]

For research use only. We do not sell to patients. ENMD-2076 Tartrate CAS No. : 1291074-87-7 Biological Activity：ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC50s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively. Research Area：Cancer Targets：FLT3|VEGFR|Src|Aurora Kinase|FGFR|Apoptosis|PDGFR Related Screening Libraries:Drug Repurposing Compound […]

For research use only. We do not sell to patients. Barasertib-HQPA CAS No. : 722544-51-6 Biological Activity：Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib-HQPA (AZD2811) induces growth arrest and apoptosis in cancer cells. Research Area：Cancer Targets：Aurora Kinase|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library […]

For research use only. We do not sell to patients. Isradipine CAS No. : 75695-93-1 Biological Activity：Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable […]

For research use only. We do not sell to patients. HPOB CAS No. : 1429651-50-2 Biological Activity：HPOB is a highly potent and selective inhibitor of HDAC6 with an IC50 of 56 nM. HPOB displays >30 fold less potent against other HDACs. HPOB enhances the effectiveness of DNA-damaging anticancer agents in transformed cells but not normal […]

For research use only. We do not sell to patients. Maytansinol CAS No. : 57103-68-1 Biological Activity：Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro. Target: Microtubule/Tubulin in vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and […]

For research use only. We do not sell to patients. bpV(phen) CAS No. : 42494-73-5 Biological Activity：bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in […]