Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Diclofenac Sodium CAS No. : 15307-79-6 Biological Activity：Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine […]

For research use only. We do not sell to patients. Isatin CAS No. : 91-56-5 Biological Activity：Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and […]

For research use only. We do not sell to patients. C646 CAS No. : 328968-36-1 Biological Activity：C646 is a selective and competitive histone acetyltransferase p300 inhibitor with Ki of 400 nM, and is less potent for other acetyltransferases. Research Area：Cancer Targets：Epigenetic Reader Domain|Autophagy|Apoptosis|Histone Acetyltransferase Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Histone Modification […]

For research use only. We do not sell to patients. Rhosin CAS No. : 1173671-63-0 Biological Activity：Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin […]

For research use only. We do not sell to patients. Gemfibrozil CAS No. : 25812-30-0 Biological Activity：Gemfibrozil is an activator of PPAR-α, used as a lipid-lowering drug; Gemfibrozil is also a nonselective inhibitor of several P450 isoforms, with Ki values for CYP2C9, 2C19, 2C8, and 1A2 of 5.8, 24, 69, and 82 μM, respectively. Research […]

For research use only. We do not sell to patients. ZM 336372 CAS No. : 208260-29-1 Biological Activity：ZM 336372 is a potent inhibitor of the protein kinase c-Raf. The IC50 value is 0.07 μM in the standard assay, which contains 0.1 mM ATP. Research Area：Cancer Targets：Raf|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound […]

For research use only. We do not sell to patients. Fenbendazole CAS No. : 43210-67-9 Biological Activity：Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator […]

For research use only. We do not sell to patients. MI-1061 TFA CAS No. : 1410737-35-7 Biological Activity：MI-1061 TFA is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 TFA potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity. Research Area：Cancer […]

For research use only. We do not sell to patients. CK2/ERK8-IN-1 CAS No. : 1085822-09-8 Biological Activity：CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, […]

For research use only. We do not sell to patients. SC144 CAS No. : 895158-95-9 Biological Activity：SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 […]