Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Crenolanib CAS No. : 670220-88-9 Biological Activity：Crenolanib is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 0.74 nM and 2.1 nM/3.2 nM, respectively. Research Area：Cancer Targets：FLT3|Autophagy|PDGFR Related Screening Libraries:Drug Repurposing […]

For research use only. We do not sell to patients. MPI-0479605 CAS No. : 1246529-32-7 Biological Activity：MPI-0479605 is a potent and selective ATP-competitive inhibitor of Mps1, with an IC50 of 1.8 nM. Research Area：Cancer Targets：Mps1|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Cytoskeleton Compound Library; […]

For research use only. We do not sell to patients. Dronedarone CAS No. : 141626-36-0 Biological Activity：Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and […]

For research use only. We do not sell to patients. Amuvatinib CAS No. : 850879-09-3 Biological Activity：Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA […]

For research use only. We do not sell to patients. Haemanthamine CAS No. : 466-75-1 Biological Activity：Haemanthamine is a crinine-type alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. Haemanthamine targets ribosomal that inhibits protein biosynthesis during the elongation stage of translation. Haemanthamine has pro-apoptotic, antioxidant, antiviral, antimalarial and anticonvulsant activities[2]. Research Area：Cancer|Infection|Neurological Disease […]

For research use only. We do not sell to patients. WDR5-IN-1 CAS No. : 2408842-51-1 Biological Activity：WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a Kd of

For research use only. We do not sell to patients. SB-218078 CAS No. : 135897-06-2 Biological Activity：SB-218078 is a potent, selective, ATP-competitive and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC50 of 250 nM) and PKC (IC50 of […]

For research use only. We do not sell to patients. Ro 90-7501 CAS No. : 293762-45-5 Biological Activity：Ro 90-7501 is an amyloid β42 (Aβ42) fibril assembly inhibitor that reduces Aβ42-induced cytotoxicity (EC50 of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) […]

For research use only. We do not sell to patients. (R)-Verapamil hydrochloride CAS No. : 38176-02-2 Biological Activity：(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer drugs[2]. Research Area：Cancer Targets：P-glycoprotein|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library […]

For research use only. We do not sell to patients. MPT0B392 CAS No. : 1346169-92-3 Biological Activity：MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK […]