Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Bucladesine sodium CAS No. : 16980-89-5 Biological Activity：Bucladesine sodium salt (Dibutyryl-cAMP sodium salt) is a stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of cAMP. Bucladesine sodium salt is also a phosphodiesterase (PDE) inhibitor. Bucladesine sodium […]

For research use only. We do not sell to patients. Enoxacin CAS No. : 74011-58-8 Biological Activity：Enoxacin (AT 2266), a fluoroquinolone, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. […]

For research use only. We do not sell to patients. m-3M3FBS CAS No. : 200933-14-8 Biological Activity：m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis[2][3]. Research Area：Cancer Targets：Apoptosis|Phospholipase Related Screening […]

For research use only. We do not sell to patients. TG101209 CAS No. : 936091-14-4 Biological Activity：TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations. […]

For research use only. We do not sell to patients. Levosimendan CAS No. : 141505-33-1 Biological Activity：Levosimendan (Simsndan; OR-1259) is a calcium sensitiser used in the management of acutely decompensated congestive heart failure. Research Area：Cardiovascular Disease Targets：Phosphodiesterase (PDE)|Autophagy|Potassium Channel Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Membrane […]

For research use only. We do not sell to patients. Urolithin B CAS No. : 1139-83-9 Biological Activity：Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and […]

For research use only. We do not sell to patients. Etoposide phosphate CAS No. : 117091-64-2 Biological Activity：Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces […]

For research use only. We do not sell to patients. Thiocolchicine CAS No. : 2730-71-4 Biological Activity：Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell […]

For research use only. We do not sell to patients. Propiconazole-d3 nitrate CAS No. : 2699607-26-4 Biological Activity：Propiconazole-d3 nitrate is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome […]

For research use only. We do not sell to patients. Epothilone A CAS No. : 152044-53-6 Biological Activity：Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers, with a Ki of 0.6-1.4 μM. Research Area：Cancer Targets：Microtubule/Tubulin|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell […]