Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Barasertib CAS No. : 722543-31-9 Biological Activity：Barasertib (AZD1152), a pro-drug of Barasertib-hQPA, is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib (AZD1152) induces growth arrest and apoptosis in cancer cells. Research Area：Cancer Targets：Aurora Kinase|Apoptosis Related Screening […]

For research use only. We do not sell to patients. SBE13 Hydrochloride CAS No. : 1052532-15-6 Biological Activity：SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 Hydrochloride poorly inhibits Plk2 (IC50>66 μM) or Plk3 (IC50=875 nM). Research Area：Cancer Targets：Autophagy|Polo-like Kinase (PLK)|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. CI-1040 CAS No. : 212631-79-3 Biological Activity：CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1. Research Area：Cancer Targets：MEK|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation […]

For research use only. We do not sell to patients. PF-543 Citrate CAS No. : 1415562-83-2 Biological Activity：PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. […]

For research use only. We do not sell to patients. NPS-1034 CAS No. : 1221713-92-3 Biological Activity：NPS-1034 is a dual inhibitor of AXL and MET with IC50s of 10.3 and 48 nM, respectively. Research Area：Cancer Targets：c-Met/HGFR|Apoptosis|TAM Receptor Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Anti-Cancer Compound Library;Anti-Lung Cancer Compound […]

For research use only. We do not sell to patients. Dasatinib hydrochloride CAS No. : 854001-07-3 Biological Activity：Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with […]

For research use only. We do not sell to patients. CPT-Se4 Biological Activity：CPT-Se4, a selenoprodrug of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT-Se4 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se4 shows cytotoxicity […]

For research use only. We do not sell to patients. Dronedarone Hydrochloride CAS No. : 141625-93-6 Biological Activity：Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents. Research Area：Cardiovascular Disease Targets：Autophagy|Potassium Channel Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound […]

For research use only. We do not sell to patients. Tricetin CAS No. : 520-31-0 Biological Activity：Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson’s disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway. Research Area：Cancer|Inflammation/Immunology|Neurological Disease Targets：Keap1-Nrf2|Apoptosis Related Small Molecules:Physalin […]

For research use only. We do not sell to patients. Sodium dichloroacetate CAS No. : 2156-56-1 Biological Activity：Sodium dichloroacetate is a metabolic regulator in cancer cells’ mitochondria with anticancer activity. Sodium dichloroacetate inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. Sodium dichloroacetate increases reactive oxygen species (ROS) generation and promotes cancer cell […]