Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Cl-amidine TFA CAS No. : 1043444-18-3 Biological Activity：Cl-amidine TFA is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine TFA induces apoptosis in cancer cells. Cl-amidine TFA induces microRNA […]

For research use only. We do not sell to patients. Propiconazole-d7 CAS No. : 1246818-14-3 Biological Activity：Propiconazole-d7 is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and […]

For research use only. We do not sell to patients. Casein Kinase inhibitor A86 CAS No. : 2079069-01-3 Biological Activity：Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and […]

For research use only. We do not sell to patients. CKLF1-C27 TFA Biological Activity：CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates ERK1/2 pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research. Research Area：Inflammation/Immunology Targets：CCR|ERK […]

For research use only. We do not sell to patients. PHT-427 CAS No. : 1191951-57-1 Biological Activity：PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 µM and 5.2 µM and for Akt and PDPK1, respectively. Research Area：Cancer Targets：Akt|Apoptosis Related Screening […]

For research use only. We do not sell to patients. LY2409881 trihydrochloride CAS No. : 946518-60-1 Biological Activity：LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM. Research Area：Cancer Targets：IKK|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;NF-κB Signaling Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer […]

For research use only. We do not sell to patients. PD180970 CAS No. : 287204-45-9 Biological Activity：PD180970 is a highly potent and ATP-competitive p210Bcr-Abl kinase inhibitor, with an IC50 of 5 nM for inhibiting the autophosphorylation of p210Bcr-Abl. PD180970 also inhibits Src and KIT kinase with IC50s of 0.8 nM and 50 nM, respectively. PD180970 […]

For research use only. We do not sell to patients. (+)-Nortrachelogenin CAS No. : 61521-74-2 Biological Activity：(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity. Research Area：Cancer Targets：Apoptosis|PI3K Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Umbralisib hydrochloride;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;STAT3-IN-10 Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural […]

For research use only. We do not sell to patients. AG1024 CAS No. : 65678-07-1 Biological Activity：AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity[2]. Research Area：Cancer|Endocrinology Targets：Insulin Receptor|IGF-1R|Apoptosis Related Screening Libraries:Covalent […]

For research use only. We do not sell to patients. AS2863619 free base CAS No. : 2241300-50-3 Biological Activity：AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 […]