Tag: Inhibitor|Activator

For research use only. We do not sell to patients. OTS964 hydrochloride CAS No. : 1338545-07-5 Biological Activity：OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to […]

For research use only. We do not sell to patients. Hydrochlorothiazid-13C,d2 CAS No. : 1190006-03-1 Biological Activity：Hydrochlorothiazid-13C,d2 is the 13C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic drug of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide […]

For research use only. We do not sell to patients. Fedratinib CAS No. : 936091-26-8 Biological Activity：Fedratinib (TG-101348) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. Fedratinib induces cancer cell apoptosis […]

For research use only. We do not sell to patients. K-Ras(G12C) inhibitor 12 CAS No. : 1469337-95-8 Biological Activity：K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM. IC50 value: 0.32 μM (EC50) Target: K-Ras Binding of K-Ras(G12C) inhibitor 12 to K-Ras(G12C) disrupts […]

For research use only. We do not sell to patients. HJC0416 hydrochloride CAS No. : 2415263-08-8 Biological Activity：HJC0416 hydrochloride is a potent and orally active STAT3 inhibitor with an enhanced anticancer profile than Stattic (HY-13818). HJC0416 hydrochloride is a promising anti-cancer agent for breast cancer study. Research Area：Cancer Targets：STAT|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Cirsilineol;Ecteinascidin […]

For research use only. We do not sell to patients. Flufenamic acid-d4 CAS No. : 1185071-99-1 Biological Activity：Flufenamic acid-d4 is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ […]

For research use only. We do not sell to patients. DC661 CAS No. : 1872387-43-3 Biological Activity：DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity. Research Area：Cancer Targets：Autophagy|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library; Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic […]

For research use only. We do not sell to patients. Prinomastat CAS No. : 192329-42-3 Biological Activity：Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3 and MMP-9 with Kis of 0.05 nM, 0.3 nM […]

For research use only. We do not sell to patients. Arnicolide D CAS No. : 34532-68-8 Biological Activity：Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in […]

For research use only. We do not sell to patients. Linifanib CAS No. : 796967-16-3 Biological Activity：Linifanib (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively. Linifanib shows prominent antitumor activity. Linifanib has much […]