Tag: Inhibitor|Activator

For research use only. We do not sell to patients. Danthron CAS No. : 117-10-2 Biological Activity：Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK. Research Area：Cancer Targets：Autophagy|Bacterial|Virus Protease|AMPK Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved […]

For research use only. We do not sell to patients. Antitumor agent-42 Biological Activity：Antitumor agent-42 (Compound 15h) is a bifunctional agent exhibiting both tubulin polymerized inhibition and NO-releasing activities, resulting in potent anti-angiogenesis, colony formation inhibition, cell cycle arrest and apoptosis induction effects. Research Area：Cancer Targets：Microtubule/Tubulin|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Tirbanibulin dihydrochloride;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II […]

For research use only. We do not sell to patients. Silmitasertib sodium salt CAS No. : 1309357-15-0 Biological Activity：Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α’. Research Area：Cancer Targets：Autophagy|Casein Kinase Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive […]

For research use only. We do not sell to patients. SC-43 CAS No. : 1400989-25-4 Biological Activity：SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects[2]. Research Area：Cancer Targets：STAT|Phosphatase|Apoptosis Related Screening Libraries:Covalent Screening Library Plus;Drug Repurposing […]

For research use only. We do not sell to patients. Top/HDAC-IN-1 Biological Activity：Top/HDAC-IN-1 (Compound 29b) is a topoisomerase/HDAC dual inhibitor with IC50s of 18, 230, 790, 87, and 5250 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. Top/HDAC-IN-1 exhibits potent antitumor activities against the HCT116 cell line with the IC50 of 180 nM. Top/HDAC-IN-1 […]

For research use only. We do not sell to patients. SBI-0206965 CAS No. : 1884220-36-3 Biological Activity：SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. Research Area：Cancer Targets：Autophagy|ULK|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound […]

For research use only. We do not sell to patients. KRIBB11 CAS No. : 342639-96-7 Biological Activity：KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 μM. Research Area：Cancer Targets：HSP|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Cytoskeleton Compound Library;Transcription Factor-Targeted […]

For research use only. We do not sell to patients. IITZ-01 CAS No. : 1807988-47-1 Biological Activity：IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. Research Area：Cancer Targets：Autophagy|Apoptosis|PI3K Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound […]

For research use only. We do not sell to patients. KW-2449 CAS No. : 1000669-72-6 Biological Activity：KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively. Research Area：Cancer Targets：FLT3|Bcr-Abl|Aurora Kinase|FGFR|Apoptosis Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA […]

For research use only. We do not sell to patients. Sunitinib CAS No. : 557795-19-4 Biological Activity：Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2]. […]