Tag: Inducer|p53 Activator

For research use only. We do not sell to patients. APE1-IN-2 Biological Activity：APE1-IN-2 (compound AP1) is a Pt(IV) prodrug, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1). APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals. Research Area：Cancer Targets：MDM-2/p53|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin […]

For research use only. We do not sell to patients. RITA CAS No. : 213261-59-7 Biological Activity：RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links. Research Area：Cancer Targets：DNA Alkylator/Crosslinker|Autophagy|MDM-2/p53 Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Anti-Cancer Compound Library;Autophagy […]

For research use only. We do not sell to patients. NSC 146109 hydrochloride CAS No. : 59474-01-0 Biological Activity：NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and […]