Tag: Inducer|Inhibitor|Activator

For research use only. We do not sell to patients. Valproic acid-d14 sodium Biological Activity：Valproic acid-d14 (sodium) is deuterium labeled Valproic acid (sodium). Valproic acid sodium salt (Sodium Valproate) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. […]

For research use only. We do not sell to patients. Simvastatin CAS No. : 79902-63-9 Biological Activity：Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. Research Area：Cardiovascular Disease|Cancer Targets：Ferroptosis|Autophagy|Mitophagy|HMG-CoA Reductase (HMGCR)|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;Bioactive Compound Library Plus; Related Small Molecules:Physalin A;Bomedemstat […]

For research use only. We do not sell to patients. Resveratrol-13C6 Biological Activity：Resveratrol-13C6 (trans-Resveratrol-13C6) is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a […]

For research use only. We do not sell to patients. Astaxanthin CAS No. : 472-61-7 Biological Activity：Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression […]

For research use only. We do not sell to patients. ABT-737 CAS No. : 852808-04-9 Biological Activity：ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic […]

For research use only. We do not sell to patients. Sinomenine hydrochloride CAS No. : 6080-33-7 Biological Activity：Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor[2]. Research Area：Cancer|Inflammation/Immunology|Neurological Disease Targets：Opioid Receptor|Autophagy|NF-κB|Apoptosis Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library […]

For research use only. We do not sell to patients. Bardoxolone methyl CAS No. : 218600-53-4 Biological Activity：Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. Research Area：Cancer Targets：Ferroptosis|Autophagy|Keap1-Nrf2|Apoptosis […]

For research use only. We do not sell to patients. Ivermectin CAS No. : 70288-86-7 Biological Activity：Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 […]

For research use only. We do not sell to patients. Lapatinib ditosylate monohydrate CAS No. : 388082-78-8 Biological Activity：Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. Research Area：Cancer Targets：EGFR|Ferroptosis|Autophagy Related Screening […]

For research use only. We do not sell to patients. (+/-)-Epigallocatechin Gallate-13C3 Biological Activity：(+/-)-Epigallocatechin Gallate-13C3 is the 13C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, […]