Tag: Inducer|Inhibitor|Activator

For research use only. We do not sell to patients. Etoposide-13C,d3 Biological Activity：Etoposide-13C,d3 is the 13C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy. Research Area：Cancer|Infection Targets：Topoisomerase|Autophagy|Mitophagy|Bacterial|Antibiotic|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Sandramycin;LLO (91-99);Gepotidacin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Oritavancin;Lobetyolin;Monascorubrin;Azlocillin sodium […]

For research use only. We do not sell to patients. Sorafenib CAS No. : 284461-73-0 Biological Activity：Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 […]

For research use only. We do not sell to patients. Panobinostat-d4 CAS No. : 1185237-51-7 Biological Activity：Panobinostat-d4 (LBH589-d4) is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in […]

For research use only. We do not sell to patients. AZT triphosphate CAS No. : 92586-35-1 Biological Activity：AZT triphosphate (3′-Azido-3′-deoxythymidine-5′-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate also inhibits the DNA polymerase of HBV. AZT triphosphate activates the mitochondria-mediated apoptosis pathway[2][3]. Research […]

For research use only. We do not sell to patients. Salicylic acid CAS No. : 69-72-7 Biological Activity：Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Research Area：Inflammation/Immunology|Cancer Targets：Autophagy|Mitophagy|Endogenous Metabolite|Apoptosis|COX Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound […]

For research use only. We do not sell to patients. Doxorubicin CAS No. : 23214-92-8 Biological Activity：Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces […]

For research use only. We do not sell to patients. Rotundic acid CAS No. : 20137-37-5 Biological Activity：Rotundic acid, a triterpenoid obtained from Ilex rotunda Thunb., induces DNA damage and cell apoptosis in hepatocellular carcinoma through AKT/mTOR and MAPK Pathways. Rotundic acid possesses anti-inflammatory and cardio-protective abilities. Research Area：Inflammation/Immunology|Cardiovascular Disease|Cancer Targets：Akt|mTOR|p38 MAPK|Apoptosis Related Screening Libraries:Natural […]

For research use only. We do not sell to patients. Nrf2/HO-1 activator 2 Biological Activity：Nrf2/HO-1 activator 2 (compound 13m), difluoro-substituted derivative, is a potent Nrf2/HO-1 activator. Nrf2/HO-1 activator 2 has neuroprotective and antioxidant effects through the Nrf2/HO-1 pathway mediated by phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. Nrf2/HO-1 activator 2 can be used […]

For research use only. We do not sell to patients. Laduviglusib CAS No. : 252917-06-9 Biological Activity：Laduviglusib (CHIR-99021) is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. […]

For research use only. We do not sell to patients. PROTAC BRD4 Degrader-6 CAS No. : 2410947-56-5 Biological Activity：PROTAC BRD4 Degrader-6 (compound 32a) is a potent small-molecule BRD4 degrader with IC50 value of 2.7 nM for BRD4 BD1. PROTAC BRD4 Degrader-6 potently degrades BRD4 protein and inhibits the expression of c-Myc. PROTAC BRD4 Degrader-6 inhibits […]