Tag: Inducer|Inhibitor|Activator

For research use only. We do not sell to patients. FX-11 CAS No. : 213971-34-7 Biological Activity：FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) specific inhibitor, with a Ki of 8 μM. FX-11 can effectively activate PKM2 (pyruvate kinase M2). FX-11 reduces ATP levels and induces oxidative stress, ROS production and […]

For research use only. We do not sell to patients. Sulfasalazine CAS No. : 599-79-1 Biological Activity：Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[2][3][4]. Research Area：Cancer|Infection|Inflammation/Immunology Targets：Ferroptosis|Autophagy|NF-κB|Bacterial|Antibiotic|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug […]

For research use only. We do not sell to patients. Sunitinib-d4 CAS No. : 1126721-79-6 Biological Activity：Sunitinib-d4 (SU 11248-d4) is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of […]

For research use only. We do not sell to patients. 2-Methoxyestradiol CAS No. : 362-07-2 Biological Activity：2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces […]

For research use only. We do not sell to patients. AZT triphosphate TEA Biological Activity：AZT triphosphate TEA (3′-Azido-3′-deoxythymidine-5′-triphosphate TEA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TEA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TEA also inhibits the DNA polymerase of HBV. AZT triphosphate TEA activates the mitochondria-mediated apoptosis […]

For research use only. We do not sell to patients. Sorafenib-d3 CAS No. : 1130115-44-4 Biological Activity：Sorafenib-d3 (Bay 43-9006-d3) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively. Research Area：Cancer Targets：Ferroptosis|FLT3|Autophagy|Raf|VEGFR|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;(Z)-FeCP-oxindole;CIL56;DB0614;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Avutometinib;Lobetyolin;BJE6-106;Dinaciclib;VEGFR-2-IN-24;Ecteinascidin 770;MDM2-p53-IN-15;BMS-690514;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II […]

For research use only. We do not sell to patients. Bucladesine calcium CAS No. : 938448-87-4 Biological Activity：Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase (PDE) […]

For research use only. We do not sell to patients. KDM1/CDK1-IN-1 Biological Activity：KDM1/CDK1-IN-1 (compound 4) is a potent KDM1 and CDK1 inhibitor, with IC50 values of 0.096 and 0.078 μM, respectively.KDM1/CDK1-IN-1 induces cell cycle arrest at G2/M phase and apoptosis in HOP-92 cells. KDM1/CDK1-IN-1 exhibits potent cytotoxic activity against the CCRF-CEM, HOP-92 and Hep-G2 cells, […]

For research use only. We do not sell to patients. Simvastatin-d6 CAS No. : 1002347-71-8 Biological Activity：Simvastatin-d6 (MK 733-d6) is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. Research Area：Cardiovascular Disease|Cancer Targets：Ferroptosis|Autophagy|Mitophagy|HMG-CoA Reductase (HMGCR)|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;CIL56;DB0614;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor […]

For research use only. We do not sell to patients. Panobinostat-d4 hydrochloride Biological Activity：Panobinostat-d4 (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat […]