Master of Bioactive Molecules | Inhibitors, Screening Libraries & Proteins
For research use only. We do not sell to patients. Sorafenib-13C,d3 CAS No. : 1210608-86-8 Biological Activity：Sorafenib-13C,d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s […]
For research use only. We do not sell to patients. Ruxolitinib CAS No. : 941678-49-5 Biological Activity：Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy[3]. Research […]
For research use only. We do not sell to patients. Chloramphenicol CAS No. : 56-75-7 Biological Activity：Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial […]
For research use only. We do not sell to patients. Etoposide CAS No. : 33419-42-0 Biological Activity：Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy. Research Area：Cancer|Infection Targets：Topoisomerase|Autophagy|Mitophagy|Bacterial|Antibiotic|Apoptosis Related Screening Libraries:Natural Product Library Plus;Drug Repurposing Compound Library Plus;FDA-Approved Drug Library […]
For research use only. We do not sell to patients. Quercetin-d3 CAS No. : 263711-79-1 Biological Activity：Quercetin-d3 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, […]
For research use only. We do not sell to patients. Tripterin CAS No. : 34157-83-0 Biological Activity：Tripterin (Celastrol) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Research Area：Inflammation/Immunology|Cancer Targets：Autophagy|Mitophagy|Proteasome|Endogenous Metabolite|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation […]
For research use only. We do not sell to patients. Dimethyl fumarate CAS No. : 624-49-7 Biological Activity：Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl […]
For research use only. We do not sell to patients. Valproic acid sodium CAS No. : 1069-66-5 Biological Activity：Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates […]
For research use only. We do not sell to patients. Resveratrol-d4 CAS No. : 1089051-56-8 Biological Activity：Resveratrol-d4 (trans-Resveratrol-d4) is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA […]
For research use only. We do not sell to patients. Theophylline CAS No. : 58-55-9 Biological Activity：Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the […]