Tag: Inducer|Inhibitor|Activator

For research use only. We do not sell to patients. Quercetin-13C3 Biological Activity：Quercetin-13C3 is the 13C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively. Research Area：Cancer Targets：Autophagy|Reactive Oxygen […]

For research use only. We do not sell to patients. Doxorubicin hydrochloride CAS No. : 25316-40-9 Biological Activity：Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal […]

For research use only. We do not sell to patients. C2 Ceramide CAS No. : 3102-57-6 Biological Activity：C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial […]

For research use only. We do not sell to patients. Mammea A/BA CAS No. : 5224-54-4 Biological Activity：Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea […]

For research use only. We do not sell to patients. Ionomycin calcium CAS No. : 56092-82-1 Biological Activity：Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces […]

For research use only. We do not sell to patients. Gliotoxin CAS No. : 67-99-2 Biological Activity：Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces […]

For research use only. We do not sell to patients. Emamectin Benzoate CAS No. : 155569-91-8 Biological Activity：Emamectin Benzoate (MK-244) is an orally active nervoussystem toxicant by binding g-aminobutyric (GABA) receptor in insects. Emamectin Benzoate is one of semi-synthetic derivative of Avermectin (HY-15311) with a broadspectrum of insecticidal and acaricidal activity. Emamectin Benzoate induces ROS-mediated […]

For research use only. We do not sell to patients. Lapatinib-d5 CAS No. : 2748212-14-6 Biological Activity：Lapatinib-d5 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. Research Area：Cancer Targets：EGFR|Ferroptosis|Autophagy Related Small Molecules:CIL56;DB0614;NSC81111;pp60 […]

For research use only. We do not sell to patients. Nrf2/HO-1 activator 1 Biological Activity：Nrf2/HO-1 activator 1 (Compound 24) is a potent Nrf2/HO-1 activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson’s disease (PD) research. Research Area：Neurological Disease Targets：Akt|Keap1-Nrf2|Reactive Oxygen Species|JNK|ERK Related Small Molecules:D-α-Hydroxyglutaric acid […]

For research use only. We do not sell to patients. Theophylline sodium glycinate CAS No. : 8000-10-0 Biological Activity：Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase […]