Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Lamotrigine-13C,d3 CAS No. : 2517756-06-6 Biological Activity：Lamotrigine-13C,d3 is the 13C- and deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for […]

For research use only. We do not sell to patients. HBX 41108 CAS No. : 924296-39-9 Biological Activity：HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 […]

For research use only. We do not sell to patients. Camptothecin CAS No. : 7689-03-4 Biological Activity：Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by […]

For research use only. We do not sell to patients. Afatinib impurity 11 CAS No. : 1402086-20-7 Biological Activity：Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Research Area：Cancer Targets：EGFR|Autophagy […]

For research use only. We do not sell to patients. Temsirolimus-d7 CAS No. : 1132660-51-5 Biological Activity：Temsirolimus-d7 (CCI-779-d7) is the deuterium labeled Temsirolimus. Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM. Temsirolimus activates autophagy and prevents deterioration of cardiac function in animal model[8]. Research Area：Cancer Targets：Autophagy|mTOR|Apoptosis Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Physalin […]

For research use only. We do not sell to patients. Laquinimod CAS No. : 248281-84-7 Biological Activity：Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic NF-κB activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing remitting (RR) and chronic progressive […]

For research use only. We do not sell to patients. Dapivirine-d11 CAS No. : 1329613-10-6 Biological Activity：Dapivirine-d11 (TMC120-d11) is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, […]

For research use only. We do not sell to patients. Trametinib-13C,d3 CAS No. : 2712126-59-3 Biological Activity：Trametinib-13C,d3 is the 13C- and deuterium labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis[2]. Research Area：Cancer Targets：MEK|Autophagy|Apoptosis Related Small […]

For research use only. We do not sell to patients. HP590 Biological Activity：HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis. Research Area：Cancer Targets：STAT|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Cirsilineol;Ecteinascidin 770;MDM2-p53-IN-15;Ochromycinone;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant […]

For research use only. We do not sell to patients. Cyasterone CAS No. : 17086-76-9 Biological Activity：Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). Cyasterone manifests anti-proliferation effect by induced apoptosis and cell cycle arrests. Cyasterone may serves as a therapeutic anti-tumor agent against human tumors. Research Area：Cancer Targets：EGFR|Apoptosis Related Screening […]