Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. Albendazole CAS No. : 54965-21-8 Biological Activity：Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits […]

For research use only. We do not sell to patients. Obatoclax CAS No. : 803712-67-6 Biological Activity：Obatoclax (GX15-070), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2[2]. Obatoclax induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax has anti-cancer and broad-spectrum antiparasitic activity[3][4]. Research […]

For research use only. We do not sell to patients. R1530 CAS No. : 882531-87-5 Biological Activity：R1530 is a highly potent, orally active, dual-acting mitosis/angiogenesis inhibitor, with anti-tumor and anti-angiogenic activities. R1530 is a multikinase inhibitor which binds to 31 kinases with Kd values of

For research use only. We do not sell to patients. Mitoxantrone dihydrochloride CAS No. : 70476-82-3 Biological Activity：Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity[2][3][4]. […]

For research use only. We do not sell to patients. Genistein-d4 CAS No. : 187960-08-3 Biological Activity：Genistein-d4 (NPI 031L-d4) is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and […]

For research use only. We do not sell to patients. MMRi62 CAS No. : 352693-80-2 Biological Activity：MMRi62, a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation […]

For research use only. We do not sell to patients. hCAIX/XII-IN-1 Biological Activity：hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the KI values of 0.48 µM and 0.83 µM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells. Research Area：Cancer Targets：Carbonic Anhydrase|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin […]

For research use only. We do not sell to patients. AS1949490 CAS No. : 1203680-76-5 Biological Activity：AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.34, 0.62, 13, >50, >50, and >50 µM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases […]

For research use only. We do not sell to patients. LW6 CAS No. : 934593-90-5 Biological Activity：LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor with an IC50 of 4.4 μM. LW6 decreases HIF-1α protein expression without affecting HIF-1β expression. Research Area：Cancer Targets：HIF/HIF Prolyl-Hydroxylase|Apoptosis Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease […]

For research use only. We do not sell to patients. BML-277 CAS No. : 516480-79-8 Biological Activity：BML-277 is a selective checkpoint kinase 2 (Chk2) inhibitor with an IC50 of 15 nM. Research Area：Cancer Targets：Apoptosis|Checkpoint Kinase (Chk) Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Targeted Diversity […]