Tag: Inducer|Inhibitor

For research use only. We do not sell to patients. 5-Fluorouracil-d1 CAS No. : 90344-84-6 Biological Activity：5-Fluorouracil-d1 (5-FU-d1) is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used […]

For research use only. We do not sell to patients. Lobetyolin CAS No. : 129277-38-9 Biological Activity：Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism[2]. Research Area：Metabolic Disease Targets：Xanthine Oxidase|Apoptosis Related Screening Libraries:Natural Product […]

For research use only. We do not sell to patients. Abacavir sulfate CAS No. : 188062-50-2 Biological Activity：Abacavir sulfate (Abacavir Hemisulfate) is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir sulfate can inhibits the replication of HIV. Abacavir sulfate shows anticancer activity in prostate cancer cell lines. Abacavir sulfate can trespass the blood-brain-barrier and […]

For research use only. We do not sell to patients. Regorafenib-13C,d3 Biological Activity：Regorafenib-13C,d3 is the 13C- and deuterium labeled Regorafenib. Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Research Area：Cancer Targets：Autophagy|Raf|VEGFR|RET|PDGFR Related Small Molecules:(Z)-FeCP-oxindole;Avutometinib;VEGFR-2-IN-24;BMS-690514;PROTAC VEGFR-2 […]

For research use only. We do not sell to patients. MDM2-p53-IN-15 Biological Activity：MDM2-p53-IN-15 is a MDM2-p53 inhibitor with an IC50 value of 26.1 nM. MDM2-p53-IN-15 inhibits the proliferation of various cancer cells and induces cell apoptosis. MDM2-p53-IN-15 can be used for the research of cancer. Research Area：Cancer Targets：MDM-2/p53|Apoptosis Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase […]

For research use only. We do not sell to patients. Staurosporine CAS No. : 62996-74-1 Biological Activity：Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of […]

For research use only. We do not sell to patients. C188-9 CAS No. : 432001-19-9 Biological Activity：C188-9 (TTI-101) is a STAT3 inhibitor, with a Kd of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts[2][3][4]. […]

For research use only. We do not sell to patients. Topoisomerase I/II inhibitor 3 Biological Activity：Topoisomerase I/II inhibitor 3 (compound 7) is a potent topoisomerase I (Topo I) and II (Topo II) dual inhibitor. Topoisomerase I/II inhibitor 3 can inhibit cell proliferation, invasion and migration, and induce apoptosis by inhibiting PI3K/Akt/mTOR signaling pathway. Topoisomerase I/II […]

For research use only. We do not sell to patients. Ciclopirox-d11 Biological Activity：Ciclopirox-d11 (HOE296b-d11) is the deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. […]

For research use only. We do not sell to patients. BIX-01294 CAS No. : 935693-62-2 Biological Activity：BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine […]