Tag: Inducer|Antagonist|Inhibitor

For research use only. We do not sell to patients. Perphenazine dihydrochloride CAS No. : 2015-28-3 Biological Activity：Perphenazine dihydrochloride is an orally active dopamine receptor and histamine-1 receptor antagonist, with Ki values of 0.56 nM (D2), 0.43 nM (D3), 6 nM (5-HT2A), respectively. Perphenazine dihydrochloride also binds to Alpha-1A adrenergic receptor. Perphenazine dihydrochloride inhibits cancer […]

For research use only. We do not sell to patients. Thioridazine-d3 hydrochloride CAS No. : 1189928-36-6 Biological Activity：Thioridazine-d3 hydrochloride is the deuterium labeled Thioridazine. Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows […]

For research use only. We do not sell to patients. W-7 hydrochloride CAS No. : 61714-27-0 Biological Activity：W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 µM, respectively[2]. W-7 hydrochloride induces apoptosis and has antitumor activity[3]. Research Area：Cancer […]

For research use only. We do not sell to patients. Fasudil CAS No. : 103745-39-7 Biological Activity：Fasudil (HA-1077; AT877) is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, […]

For research use only. We do not sell to patients. Itraconazole CAS No. : 84625-61-6 Biological Activity：Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol […]

For research use only. We do not sell to patients. Fasudil hydrochloride semihydrate CAS No. : 186694-02-0 Biological Activity：Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM […]

For research use only. We do not sell to patients. (Z)-Guggulsterone CAS No. : 39025-23-5 Biological Activity：(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces […]

For research use only. We do not sell to patients. Latrepirdine dihydrochloride CAS No. : 97657-92-6 Biological Activity：Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion. Research Area：Neurological Disease|Endocrinology Targets：Adrenergic Receptor|5-HT Receptor|Autophagy|Histamine Receptor|Amyloid-β Related Screening Libraries:Drug Repurposing Compound […]

For research use only. We do not sell to patients. Novobiocin CAS No. : 303-81-1 Biological Activity：Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus […]

For research use only. We do not sell to patients. Thioridazine CAS No. : 50-52-2 Biological Activity：Thioridazine, an antagonist of the dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. Thioridazine is also a potent inhibitor of PI3K-Akt-mTOR signaling pathways with anti-angiogenic effect. Thioridazine shows antiproliferative and apoptosis induction effects in various types […]