Tag: Inducer|Activator|Inhibitor

For research use only. We do not sell to patients. AKN-028 acetate Biological Activity：AKN-028 acetate, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. AKN-028 acetate inhibits FLT3 autophosphorylation. AKN-028 acetate induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 acetate induces […]

For research use only. We do not sell to patients. GEM-5 CAS No. : 2233543-49-0 Biological Activity：GEM-5 is a gemcitabine-based conjugate containing a HIF-1α inhibitor (YC-1) (IC50=30 nM). GEM-5 can significantly down-regulate the expression of HIF-1α and up-regulate the expression of tumor suppressor p53. GEM-5 induces the apoptosis of A2780 cells and inhibits tumor growth. […]

For research use only. We do not sell to patients. Pregnenolone-d4-1 CAS No. : 61574-54-7 Biological Activity：Pregnenolone-d4-1 (3β-Hydroxy-5-pregnen-20-one-d4-1) is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) […]

For research use only. We do not sell to patients. Danshensu CAS No. : 76822-21-4 Biological Activity：Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway. Research Area：Cardiovascular Disease|Cancer Targets：Autophagy|Keap1-Nrf2|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;NF-κB Signaling Compound Library;Stem Cell Signaling Compound Library;Natural […]

For research use only. We do not sell to patients. Nivalenol CAS No. : 23282-20-4 Biological Activity：Nivalenol, classified as type B trichotecenes toxins produced by Fusarium graminearum, is a fungal metabolite present in agricultural product. Nivalenol induces cell death through caspase-dependent mechanisms and via the intrinsic apoptotic pathway. Nivalenol affects the immune system, causes emesis, […]

For research use only. We do not sell to patients. Carbamazepine CAS No. : 298-46-4 Biological Activity：Carbamazepine, a sodium channel blocker, is an anticonvulsant drug. Target: Sodium channel Carbamazepine inhibits the binding of [3H]batrachotoxinin A 20-α-benzoate (BTX-B) to a receptor site of voltage-sensitive sodium channel with IC50 of 131 μM, to decrease the activation of […]

For research use only. We do not sell to patients. CPS-11 CAS No. : 145945-21-7 Biological Activity：CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines[2][3]. Research […]

For research use only. We do not sell to patients. Diallyl Trisulfide CAS No. : 2050-87-5 Biological Activity：Diallyl Trisulfide is isolated from Garlic. Diallyl Trisulfide suppresses the growth of Penicillium expansum (MFC99 value: ≤ 90 μg/mL) and promotes apoptosis via production of reactive oxygen species (ROS) and disintegration of cellular ultrastructure. Anticancer effect. Research Area：Cancer|Infection […]

For research use only. We do not sell to patients. 15-Acetoxyscirpenol CAS No. : 2623-22-5 Biological Activity：15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3. Research Area：Infection Targets：Bacterial|Antibiotic|Caspase|Apoptosis Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus; […]

For research use only. We do not sell to patients. KP372-1 CAS No. : 1374996-60-7 Biological Activity：KP372-1 is an Akt inhibitor that inhibits proliferation and induces apoptosis and anoikis. KP372-1 is also an NQO1 redox cycling agent that causes DNA damage (including DNA breakage) by generating ROS. KP372-1 can be used in cancer research (such […]