Tag: Degrader

For research use only. We do not sell to patients. PZ703b CAS No. : 2471970-56-4 Biological Activity：PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research[2]. Research Area：Cancer Targets：PROTACs Related Screening Libraries:Bioactive Compound Library Plus; Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;PROTAC […]

For research use only. We do not sell to patients. TD1092 Biological Activity：TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 promotes cancer cells death via caspase activation, inhibits NF-κB pathway and epithelial-mesenchymal transition (EMT). Research Area：Cancer Targets：IAP Related Small Molecules:Xevinapant;XIAP degrader-1;MX69;APG-1387;SBP-0636457;GDC-0152;Birinapant;SM-164;CUDC-427;BV6;SM-1295;LCL161;AZD5582;MV1;XIAP/cIAP1 antagonist-1;FL118;Polygalacin D;SM-433 hydrochloride;LBW242;UC-112;ASTX660;SM-433;Embelin Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  […]

For research use only. We do not sell to patients. KTX-951 CAS No. : 2573298-36-7 Biological Activity：KTX-951 is a PROTAC targeting IRAK4 degradation (DC50=18 nM). KTX-951 (10 mg/kg) shows the oral bioavailability (F%) of 22% in a rat model. KTX-951 has good anticancer potential. Research Area：Cancer Targets：PROTACs|IRAK Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;CCT367766 formic;HDAC6 […]

For research use only. We do not sell to patients. Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH CAS No. : 2750350-39-9 Biological Activity：Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b) is an EZH2 degrader and can be used for the research of lymphoma. Research Area：Cancer Targets：Histone Methyltransferase Related Small Molecules:EEDi-5285;EZH2-IN-2;BIX-01294;SGC707;(S)-HH2853;G9a-IN-1;UNC4976;MS1943;OTS186935 hydrochloride;MS8815;(R)-HH2853;EPZ020411;Furamidine dihydrochloride;EZH2-IN-12;UNC0642;MU1656;Chaetocin;UNC0646;UNC0224;MRK-740;SMYD2-IN-1;PRMT5-IN-21;Sinefungin;MM-401;SETDB1-TTD-IN-1;Dot1L-IN-2;PRMT5-IN-10;PRMT1-IN-1 Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  […]

For research use only. We do not sell to patients. Taragarestrant CAS No. : 2118899-51-5 Biological Activity：Taragarestrant (D-0502) is a potent, orally active and selective estrogen receptor degrader (SERD). Taragarestrant shows potent activity in various ER+ breast cancer cell lines and xenograft models[2]. Research Area：Cancer Targets：Estrogen Receptor/ERR Related Small Molecules:DS20362725;LSD1/ER-IN-1;Giredestrant;Avobenzone;Estriol-d3;Chrysin;ERRγ Inverse Agonist 1;(R)-DPN;MPP hydrochloride;GPR30 agonist-1;Diethylstilbestrol;Endoxifen;Glicoricone;ERB-196;Dihydroresveratrol;FLTX1;(Rac)-Hexestrol-d6 […]