Tag: Antagonist|Inhibitor

For research use only. We do not sell to patients. Astemizole-d3 CAS No. : 1189961-39-4 Biological Activity：Astemizole-d3 is the deuterium labeled Astemizole. Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG […]

For research use only. We do not sell to patients. PPNDS tetrasodium CAS No. : 1021868-77-8 Biological Activity：PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP […]

For research use only. We do not sell to patients. Geniposide CAS No. : 24512-63-8 Biological Activity：Geniposide is an iridoid glucoside extracted from Gardenia jasminoidesEllis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities. Research Area：Neurological Disease Targets：Influenza Virus|Amyloid-β Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound […]

For research use only. We do not sell to patients. Metergoline CAS No. : 17692-51-2 Biological Activity：Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline […]

For research use only. We do not sell to patients. Asenapine citrate CAS No. : 1411867-74-7 Biological Activity：Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder[2]. […]

For research use only. We do not sell to patients. 6-Mercaptopurine-d2 CAS No. : 82677-93-8 Biological Activity：6-Mercaptopurine-d2 (Mercaptopurine-d2) is the deuterium labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug[2]. Research Area：Cancer Targets：Nucleoside Antimetabolite/Analog|Autophagy|Endogenous Metabolite Related Small […]

For research use only. We do not sell to patients. (E)-8-(3-Chlorostyryl)caffeine CAS No. : 147700-11-6 Biological Activity：(E)-8-(3-Chlorostyryl)caffeine is a selective adenosine A2A receptor antagonist. (E)-8-(3-Chlorostyryl)caffeine inhibits monoamine oxidase B (MAO-B) with a Ki value of 70 nM by a pathway that is independent of its actions on the A2A receptor. (E)-8-(3-Chlorostyryl)caffeine has the potential for Parkinson’s disease research. Research […]

For research use only. We do not sell to patients. Carebastine CAS No. : 90729-42-3 Biological Activity：Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner. Carebastine suppresses the expression of macrophage migration inhibitory factor[2]. Research Area：Cancer|Endocrinology […]

For research use only. We do not sell to patients. Fenspiride-d5 CAS No. : 1246911-67-0 Biological Activity：Fenspiride-d5 is the deuterium labeled Fenspiride. Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 […]

For research use only. We do not sell to patients. Loxapine CAS No. : 1977-10-2 Biological Activity：Loxapine is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent[4]. Research Area：Neurological Disease Targets：Dopamine Receptor|5-HT Receptor|Bacterial Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Anti-Infection Compound […]