Tag: Antagonist|Inhibitor

For research use only. We do not sell to patients. 6-Mercaptopurine-13C2,15N CAS No. : 1190008-04-8 Biological Activity：6-Mercaptopurine-13C2,15N (Mercaptopurine-13C2,15N) is the 13C- and 15N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug. Research Area：Cancer Targets：Nucleoside Antimetabolite/Analog|Autophagy|Endogenous Metabolite Related […]

For research use only. We do not sell to patients. FC131 CAS No. : 606968-52-9 Biological Activity：FC131 is a potent CXCR4 antagonist. FC131 inhibits [125I]-SDF-1 binding to CXCR4 with an IC50 of 4.5 nM. FC131 has anti-HIV activity. Research Area：Infection Targets：CXCR|HIV Related Small Molecules:Nicotinamide N-oxide;HIV-1 TAT (48-60);Seletracetam lithium;HIV-IN-2;Triptonine B;Peritassine A;CXCR4 antagonist 2;Flavopiridol;AMG 487 (S-enantiomer);TAT (48-57);FGI-106 […]

For research use only. We do not sell to patients. Glaucine CAS No. : 475-81-0 Biological Activity：Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is […]

For research use only. We do not sell to patients. Picrotoxinin CAS No. : 17617-45-7 Biological Activity：Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits α1β2γ2L GABAA receptor with an IC50 of 1.15 μM. Research Area：Neurological […]

For research use only. We do not sell to patients. Ritanserin CAS No. : 87051-43-2 Biological Activity：Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors. Research Area：Neurological Disease Targets：Dopamine […]

For research use only. We do not sell to patients. Metoprolol succinate CAS No. : 98418-47-4 Biological Activity：Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties[2][3]. Research Area：Cardiovascular Disease|Endocrinology|Cancer Targets：Adrenergic Receptor|Apoptosis Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis […]

For research use only. We do not sell to patients. KRH-3955 hydrochloride CAS No. : 2253744-59-9 Biological Activity：KRH-3955 hydrochloride is an orally bioavailable CXCR4 antagonist. KRH-3955 hydrochloride inhibits SDF-1α binding to CXCR4 with an IC50 of 0.61 nM. KRH-3955 hydrochloride is also a highly potent and selective inhibitor of X4 HIV-1, with an EC50 of […]

For research use only. We do not sell to patients. Brompheniramine maleate CAS No. : 980-71-2 Biological Activity：Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, […]

For research use only. We do not sell to patients. Flavoxate CAS No. : 15301-69-6 Biological Activity：Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) […]

For research use only. We do not sell to patients. N-Desmethyltamoxifen hydrochloride CAS No. : 15917-65-4 Biological Activity：N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human […]