Tag: Antagonist

For research use only. We do not sell to patients. SR59230A CAS No. : 174689-39-5 Biological Activity：SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively[2]. Research Area：Metabolic Disease|Cardiovascular Disease Targets：Adrenergic Receptor Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G […]

For research use only. We do not sell to patients. Clebopride malate CAS No. : 57645-91-7 Biological Activity：Clebopride malate is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders. Target: dopamine Clebopride is a substituted benzamide, closely related to metoclopramide. Research Area：Metabolic Disease Targets：Dopamine Receptor Related Screening Libraries:Drug Repurposing […]

For research use only. We do not sell to patients. MK-3697 CAS No. : 1224846-01-8 Biological Activity：MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. IC50 value: 0.95 nM(Ki) Target: Orexin 2 receptor antagonist MK-3697 is a highly potent, orally bioavailable selective orexin […]

For research use only. We do not sell to patients. (Rac)-Sograzepide CAS No. : 168161-71-5 Biological Activity：(Rac)-Sograzepide is an antagonist of cholecystokinin B (CCK-B) receptor, and has the potential of reducing the secretion of gastric acid. Research Area：Metabolic Disease Targets：Cholecystokinin Receptor Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound […]

For research use only. We do not sell to patients. ANA-12 CAS No. : 219766-25-3 Biological Activity：ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively. Research Area：Neurological Disease Targets：Trk Receptor Related Screening Libraries:Bioactive Compound Library Plus;Kinase Inhibitor Library;Neuronal Signaling Compound […]

For research use only. We do not sell to patients. CXCR4 antagonist 6 CAS No. : 2304750-68-1 Biological Activity：CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated […]

For research use only. We do not sell to patients. A81988 CAS No. : 141887-34-5 Biological Activity：A81988 is a potent, competitive, non-peptidic antagonist of angiotensin AT1 receptors. Research Area：Cardiovascular Disease|Endocrinology Targets：Angiotensin Receptor Related Small Molecules:Saralasin;EMD 66684;TD-0212;Angiotensin I/II (1-6) (TFA);YS-49;TRV055;TRV056;H-Val-Pro-Pro-OH TFA;Tranilast sodium;Angiotensin amide;L162389;L-159282;CGP48369;Elisartan;Pratosartan;TRV-120027 TFA;SL910102 Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent […]

For research use only. We do not sell to patients. GSK-269984A CAS No. : 892664-04-9 Biological Activity：GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC50 of 7.9. Research Area：Neurological Disease|Endocrinology Targets：Prostaglandin Receptor Related Small Molecules:Omidenepag isopropyl;DG-041;8-Isoprostaglandin E2;BAY-6672;trans-Isoferulic acid;KMN-80;SC 51089;p-Hydroxycinnamic acid;Pexopiprant;Dinoprost;Sulprostone;Prostaglandin E2;CAY10471 Racemate;Fevipiprant;TG6-10-1;Cicaprost;ER-819762;MRE-269-d6;ONO-8130;KAG-308;KF 13218;Prostaglandin E2-d4 Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  […]

For research use only. We do not sell to patients. Nelotanserin CAS No. : 839713-36-9 Biological Activity：Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. Research Area：Cancer|Neurological Disease Targets：5-HT Receptor Related Screening […]

For research use only. We do not sell to patients. Derenofylline CAS No. : 251945-92-3 Biological Activity：Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates […]